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Holland, M. L., Groth, S. W., Smith, J. A., Meng, Y., & Kitzman, H. (2018). Low birthweight in second children after nurse home visiting. Journal of Perinatology, 38(12), 1610–1619.

Model(s) Reviewed: Nurse-Family Partnership (NFP)®
Manuscript screening details
Screening decision Screening conclusion
Passes screens Eligible for review
Study design details
Rating Design Attrition Baseline equivalence Reassignment Confounding factors
Moderate Non-experimental comparison group design Not applicable Established on race/ethnicity and SES; outcomes not feasible to assess at baseline Not applicable None
Study characteristics
Study participants The study sample consisted of 512 triads (mother, firstborn child, and second-born child): 355 triads in the comparison group and 157 triads in the treatment group. This study focused on outcomes related to the second-born child. The study participants were all participants in a larger randomized controlled trial (RCT). To be eligible for the original RCT, women had to be primiparous and demonstrate two of three risk factors: unmarried, unemployed, and not graduated from high school. Those with known chronic conditions associated with poor birth outcomes were not eligible to participate. At baseline, participants tended to be young (about 18 years old on average), low-income (discretionary income was $1,283 for the comparison group and $15 for the treatment group, on average), and African American.
Setting Memphis, Tennessee
Intervention services Mothers in the treatment group received home visits from nurses who provided support and education aimed at improving maternal health and first pregnancy outcomes, child health and development, and family economic self-sufficiency. Home visits varied from weekly to monthly from the initial pregnancy to the child’s second birthday. Mothers in the treatment group also received the services that mothers in the comparison group received.
Comparison conditions Mothers in the comparison group did not receive NFP home visiting services, but did receive transportation to prenatal care and early childhood developmental screening and referral services until the child was 2 years old.
Staff characteristics and training Not described
Funding sources University of Rochester CTSA award number TL1 TR002000 from the National Center for Advancing Translational Sciences of the National Institutes of Health.
Author affiliation None of the study authors are developers of this model.
Study Registration:

Clinicaltrials.gov Identifier: None found. Study registration was assessed by HomVEE beginning with the 2014 review.

Findings details

Child health
Rating Outcome measure Effect Sample Timing of follow-up Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes
Moderate

Low birthweight of the second child

FavorableUnfavorable or ambiguousNo Effect

Nurse Family Partnership vs. comparison, Memphis New Mother's Study 1990-1991, mothers with second child

18 years

512 children Not reported Not reported Odds ratio = 0.51 Study reported = -0.41

Statistically significant, p <0.05

Effect size based on study OR

Submitted by barbara on Fri, 04/12/2019 - 18:55

HomVEE calculated the effect size based on the study-reported odds ratio.

Moderate

Preterm birth of the second child

FavorableUnfavorable or ambiguousNo Effect

Nurse Family Partnership vs. comparison, Memphis New Mother's Study 1990-1991, mothers with second child

18 years

470 children Not reported Not reported Odds ratio = 1.07 Study reported = 0.04

Not statistically significant, p ≥ 0.05

Effect size based on study OR

Submitted by barbara on Fri, 04/12/2019 - 18:55

HomVEE calculated the effect size based on the study-reported odds ratio.

Outcome measure summary

Child health
Outcome measure Description of measure Data collection method Properties of measure

Low birthweight of the second child

Likelihood of second born child having a birthweight below 2,500 grams

Review of medical records

Not applicable

Preterm birth of the second child

Likelihood of second child being born before the 37th week of gestation

Review of medical records

Not applicable