Klinnert, M. D., Liu, A. H., Pearson, M. R., Tong, S., Strand, M, Luckow, A., & Robinson, J. L. (2007). Outcome of a randomized multifaceted intervention with low-income families of wheezing infants. Archives of Pediatrics & Adolescent Medicine, 161(8), 783-790.
| Screening decision | Screening conclusion | HomVEE procedures and standards version |
|---|---|---|
| Passes screens | Eligible for review | Version 1 |
| Rating | Design | Attrition | Baseline equivalence | Compromised randomization | Confounding factors | Valid, reliable measure(s) |
|---|---|---|---|---|---|---|
| High | Randomized controlled trial | Low | Not applicable | None | None | Not assessed in manuscripts reviewed before 2021 |
High rating applies to oral corticosteroid and emergency department visit outcomes. All other outcomes receive a low rating because of high attrition and failure to demonstrate baseline equivalence.
| Study participants | Participants (infants and their families) were recruited from local hospitals and clinics in the Denver, Colorado, area and assigned randomly to either the intervention or the comparison group. Initially 181 infants were randomly assigned, 90 to the treatment group and 91 to the comparison group. At the four-year-old follow-up that is the focus of the paper, 72 children remained in the intervention group and 77 in the control group. This follow-up sample included European Americans (21 percent treatment, 21 percent control), African American (22 percent treatment, 25 percent control), U.S.-born Hispanic (35 percent treatment, 29 percent control) and foreign-born Hispanic (22 percent treatment, 22 percent control). Approximately half of each group had incomes less than $12,000 per year. |
|---|---|
| Setting | The study was conducted in Denver, Colorado. |
| Intervention services | The intervention included home visits conducted by specially trained nurses. The intervention began when infants were from 9 to 24 months old and continued for 12 months. Participants received approximately 15 visits (or telephone calls) by a public health nurse. Each visit lasted an average of 53 minutes. |
| Comparison conditions | Comparison group members received an educational video at the baseline interview that described risk factors for developing asthma and actions that caregivers can take to mediate the risks. |
| Subgroups examined |
This field lists subgroups examined in the manuscript (even if they were not replicated in other samples and not reported on the summary page for this model’s report). • Asthma symptom severity at baseline (low severity or high severity) |
| Funding sources | National Institute of Allergy and Infectious Diseases; National Institute of Health/National Center for Research Resources. |
| Author affiliation | Mary D. Klinnert, a study author, is a developer of this model. |
| Peer reviewed | Peer reviewed status is not listed for manuscripts reviewed before 2021. |
| Rating | Outcome measure | Effect | Sample | Timing of follow-up | Sample size | Intervention group | Comparison group | Group difference | Effect size | Statistical significance | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| High | Emergency Department Visits | FavorableUnfavorable or ambiguousNo Effect |
Denver, CO sample | Between 24 and 34 months | 144 children | Unadjusted mean = 18.60 | Unadjusted mean = 24.30 | OR = 0.85 | HomVEE calculated = 0.01 | Not statistically significant, p = .72 | |
| High | Oral corticosteroid use | FavorableUnfavorable or ambiguousNo Effect |
Denver, CO sample | Between 24 and 34 months | 144 children | Unadjusted mean = 18.60 | Unadjusted mean = 24.30 | OR = 0.69 | HomVEE calculated = 0.01 | Not statistically significant, p = .44 |
