footnote130
High rating applies to oral corticosteroid and emergency department visit outcomes. All other outcomes receive a low rating because of high attrition and failure to demonstrate baseline equivalence.
Screening decision | Screening conclusion |
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Passes screens | Eligible for review |
Rating | Design | Attrition | Baseline equivalence | Reassignment | Confounding factors |
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High | Randomized controlled trial | Low | Not applicable | None | None |
High rating applies to oral corticosteroid and emergency department visit outcomes. All other outcomes receive a low rating because of high attrition and failure to demonstrate baseline equivalence.
Study participants | Participants (infants and their families) were recruited from local hospitals and clinics in the Denver, Colorado, area and assigned randomly to either the intervention or the comparison group. Initially 181 infants were randomly assigned, 90 to the treatment group and 91 to the comparison group. At the four-year-old follow-up that is the focus of the paper, 72 children remained in the intervention group and 77 in the control group. This follow-up sample included European Americans (21 percent treatment, 21 percent control), African American (22 percent treatment, 25 percent control), U.S.-born Hispanic (35 percent treatment, 29 percent control) and foreign-born Hispanic (22 percent treatment, 22 percent control). Approximately half of each group had incomes less than $12,000 per year. |
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Setting | The study was conducted in Denver, Colorado. |
Intervention services | The intervention included home visits conducted by specially trained nurses. The intervention began when infants were from 9 to 24 months old and continued for 12 months. Participants received approximately 15 visits (or telephone calls) by a public health nurse. Each visit lasted an average of 53 minutes. |
Comparison conditions | Comparison group members received an educational video at the baseline interview that described risk factors for developing asthma and actions that caregivers can take to mediate the risks. |
Staff characteristics and training | The nurses in this study had bachelor’s of science degrees in nursing and had experience in community outreach. |
Funding sources | National Institute of Allergy and Infectious Diseases; National Institute of Health/National Center for Research Resources. |
Author affiliation | Mary D. Klinnert, a study author, is a developer of this model. |
Rating | Outcome measure | Effect | Sample | Timing of follow-up | Sample size | Intervention group | Comparison group | Group difference | Effect size | Statistical significance | Notes |
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High | Emergency Department Visits | FavorableUnfavorable or ambiguousNo Effect |
Denver, CO sample | Between 24 and 34 months | 144 children | Unadjusted mean 18. 6 = 18.60 | Unadjusted mean = 24.30 | OR = 0.85 | HomeVEE calculated = 0.01 | Not statistically significant, p = .72 | |
High | Oral corticosteroid use | FavorableUnfavorable or ambiguousNo Effect |
Denver, CO sample | Between 24 and 34 months | 144 children | Unadjusted mean 18. 6 = 18.60 | Unadjusted mean = 24.30 | OR = 0.69 | HomeVEE calculated = 0.01 | Not statistically significant, p = .44 |
Outcome measure | Description of measure | Data collection method | Properties of measure |
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Emergency Department Visits |
Percentage of child emergency department visits between three and four years of age | Review of medical records | Not applicable |
Oral corticosteroid use |
Percentage of children who had a course of oral corticosteroids during the previous year. | Review of medical records | Not applicable |