Nurse-Family Partnership (NFP)® Meets HHS Criteria

Last updated: October 2019

Effects Shown in Research & Outcome Measure Details

Child Health

Outcomes Rated High

Nurse-Family Partnership (NFP)®
Show Study Effects Details
Outcome measure Effect Follow-up Timing Sample Sample Size Program Group Comparison Group Group Difference Effect size Statistical significance Outcome Type
Child birth weight (grams)
FavorableUnfavorableNo Effect
Birth Full (Elmira) 308 children Adjusted mean = 3285.00 Adjusted mean = 3262.00 Mean difference = 23.00 Not available Not statistically significant,
p > 0.05
Primary
Length of gestation
FavorableUnfavorableNo Effect
Birth Full (Elmira) 308 children Adjusted mean = 39.57 Adjusted mean = 39.71 Mean difference = -0.14 Not available Not statistically significant,
p > 0.05
Primary
Percentage low birth rate, (≤ 2,500 grams)
FavorableUnfavorableNo Effect
Birth Full (Elmira) 308 children % (adjusted) = 5.78 Adjusted mean % = 2.61 Mean difference = 3.17 HomeVEE calculated = 0.50 Not statistically significant,
p > 0.05
Primary
Percentage preterm delivery (< 37 weeks)
FavorableUnfavorableNo Effect
Birth Full (Elmira) 308 children % (adjusted) = 6.90 Adjusted mean % = 7.27 Mean difference = -0.37 HomeVEE calculated = -0.03 Not statistically significant,
p > 0.05
Primary
Show Study Outcome Measure Summary
Outcome Measure Outcome Measure Description Collection method Properties Outcome Type Operations links

Child birth weight

The child’s recorded birth weight in grams Review of medical records

Not applicable

Primary

Length of gestation

The length of gestation in weeks was estimated using newborn physical and neurologic examinations, (based on the Dubowitz procedure) and ultrasound readings taken before the 28th week of pregnancy. In the absence of examination and ultrasound data, reported last menstrual periods and measurements of uterine size made before 20 weeks were used. For low birth weight infants, gestational age was estimated using the newborn physical examination. Review of medical records

Not applicable

Primary

Percentage low birth weight

Percentage of children with birth weight less than or equal to 2,500 grams Review of medical records

Not applicable

Primary

Percentage preterm delivery

Percentage of children who were delivered at less than 37 weeks’ gestation Review of medical records

Not applicable

Primary
Nurse-Family Partnership (NFP)®
Show Study Effects Details
Outcome measure Effect Follow-up Timing Sample Sample Size Program Group Comparison Group Group Difference Effect size Statistical significance Outcome Type Notes
Alcohol and drug impairment (mother report)
FavorableUnfavorableNo Effect
15 year follow-up Nurse visited during pregnancy + infancy and comparison (Elmira) 245 adolescents Adjusted mean = 0.28 Adjusted mean = 0.18 Mean difference = -0.10 Not available Not statistically significant,
p = 0.68
Secondary
Alcohol and drug impairment (mother report)
FavorableUnfavorableNo Effect
15-year follow-up Nurse visited during pregnancy and comparison (Elmira) 277 adolescents Adjusted mean = 0.20 Adjusted mean = 0.18 Mean difference = 0.02 Not available Not statistically significant,
p = 0.96
Secondary
Alcohol impairment (self-report)
FavorableUnfavorableNo Effect
15-year follow-up Nurse visited during pregnancy and comparison (Elmira) 227 adolescents Adjusted mean = 0.50 Adjusted mean = 0.52 Mean difference = -0.02 Not available Not statistically significant,
p = 0.95
Secondary
Alcohol impairment (self-report)
FavorableUnfavorableNo Effect
15-year follow-up Nurse visited during pregnancy + infancy and comparison (Elmira) 245 adolescents Adjusted mean = 0.47 Adjusted mean = 0.52 Mean difference = -0.05 Not available Not statistically significant,
p = 0.35
Secondary
Ever had sexual intercourse
FavorableUnfavorableNo Effect
15-year follow-up Nurse visited during pregnancy and comparison (Elmira) 227 adolescents % (adjusted) = 35.00 Adjusted mean % = 35.00 Mean difference = 0.00 HomeVEE calculated = 0.00 Not statistically significant,
p = 1.00
Secondary

footnote2

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the odds ratio.

Ever pregnant or made someone pregnant
FavorableUnfavorableNo Effect
15-year follow-up Nurse visited during pregnancy and comparison (Elmira) 227 adolescents % (adjusted) = 2.00 Adjusted mean % = 3.00 Mean difference = -1.00 HomeVEE calculated = -0.25 Not statistically significant,
p = 0.97
Secondary

footnote2

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the odds ratio.

Ever pregnant or made someone pregnant
FavorableUnfavorableNo Effect
15-year follow-up Nurse visited during pregnancy + infancy and comparison (Elmira) 245 adolescents % (adjusted) = 4.00 Adjusted mean % = 3.00 Mean difference = 1.00 HomeVEE calculated = 0.18 Not statistically significant,
p = 1.00
Secondary

footnote2

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the odds ratio.

Incidence of sex partners (number)
FavorableUnfavorableNo Effect
15-year follow-up Nurse visited during pregnancy and comparison (Elmira) 227 adolescents Adjusted mean = 1.10 Adjusted mean = 1.56 Mean difference = -0.46 Not available Not statistically significant,
p = 0.48
Secondary

footnote1

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the log-incidence difference.

Incidence of sex partners (number)
FavorableUnfavorableNo Effect
15-year follow-up Nurse visited during pregnancy + infancy and comparison (Elmira) 245 adolescents Adjusted mean = 1.16 Adjusted mean = 1.56 Mean difference = -0.40 Not available Not statistically significant,
p = 0.90
Secondary

footnote1

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the log-incidence difference.

Incidence–cigarettes smoked per day
FavorableUnfavorableNo Effect
15-year follow-up Nurse visited during pregnancy and comparison (Elmira) 227 adolescents Adjusted mean = 0.91 Adjusted mean = 1.30 Mean difference = -0.39 Not available Not statistically significant,
p = 0.49
Secondary

footnote1

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the log-incidence difference.

Incidence–cigarettes smoked per day
FavorableUnfavorableNo Effect
15-year follow-up Nurse visited during pregnancy + infancy and comparison (Elmira) 245 adolescents Adjusted mean = 1.28 Adjusted mean = 1.30 Mean difference = -0.02 Not available Not statistically significant,
p = 0.76
Secondary

footnote1

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the log-incidence difference.

Incidence–days drank alcohol
FavorableUnfavorableNo Effect
15-year follow-up Nurse visited during pregnancy and comparison (Elmira) 227 adolescents Adjusted mean = 1.81 Adjusted mean = 1.57 Mean difference = 0.24 Not available Not statistically significant,
p = 0.97
Secondary

footnote1

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the log-incidence difference.

Incidence–days drank alcohol
FavorableUnfavorableNo Effect
15-year follow-up Nurse visited during pregnancy + infancy and comparison (Elmira) 245 adolescents Adjusted mean = 1.87 Adjusted mean = 1.57 Mean difference = -0.30 Not available Not statistically significant,
p = 0.96
Secondary

footnote1

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the log-incidence difference.

Incidence–days used drugs
FavorableUnfavorableNo Effect
15-year follow-up Nurse visited during pregnancy and comparison (Elmira) 227 adolescents Adjusted mean = 3.55 Adjusted mean = 2.28 Mean difference = 1.27 Not available Not statistically significant,
p = 0.49
Secondary

footnote1

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the log-incidence difference.

Incidence–days used drugs
FavorableUnfavorableNo Effect
15-year follow-up Nurse visited during pregnancy + infancy and comparison (Elmira) 245 adolescents Adjusted mean = 2.04 Adjusted mean = 2.28 Mean difference = -0.24 Not available Not statistically significant,
p = 0.54
Secondary

footnote1

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the log-incidence difference.

Show Study Outcome Measure Summary
Outcome Measure Outcome Measure Description Collection method Properties Outcome Type Operations links

Ever had sexual intercourse

Percentage of youth reporting that they had experienced sexual intercourse Youth report

Not applicable

Secondary

Ever pregnant or made someone pregnant

Percentage of youth reporting that they had ever been pregnant or made a sexual partner pregnant Youth report

Not applicable

Secondary

Incidence of sex partners

Number of sexual partners the youth had during the youth’s lifetime Youth report

Not applicable

Secondary

Incidence—cigarettes smoked per day

A variable constructed to characterize the total number of cigarettes the youth currently smoked per day Youth report

Not applicable

Secondary

Incidence—days drank alcohol

A variable constructed to characterize the number of days the youth drank alcohol during the previous 6 months Youth report

Not applicable

Secondary

Incidence—days used drugs

A variable constructed to characterize the number of days the youth used illegal drugs during the previous 6 months Youth report

Not applicable

Secondary

Incidence—long-term school suspensions

Number of long-term school suspensions the youth had received Review of school records

Not applicable

Primary

Incidence—short-term school suspensions

Number of short-term school suspensions the youth had received Review of school records

Not applicable

Primary
Nurse-Family Partnership (NFP)®
Show Study Effects Details
Outcome measure Effect Follow-up Timing Sample Sample Size Program Group Comparison Group Group Difference Effect size Statistical significance Outcome Type Notes
Subsequent NICU/special care admission (rate per subsequent birth)
FavorableUnfavorableNo Effect
6-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 641 mothers % (adjusted) = 18.00 Adjusted mean % = 23.00 OR = -0.72 HomeVEE calculated = -0.20 Not statistically significant,
p = 0.14
Secondary

footnote2

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the odds ratio.

Subsequent low birth weight newborn (rate per subsequent birth)
FavorableUnfavorableNo Effect
6-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 641 mothers % (adjusted) = 11.00 Adjusted mean % = 16.00 OR = -0.69 HomeVEE calculated = -0.22 Not statistically significant,
p = 0.16
Secondary

footnote2

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the odds ratio.

Show Study Outcome Measure Summary
Outcome Measure Outcome Measure Description Collection method Properties Outcome Type Operations links

Subsequent NICU or special care admission

Rate of subsequent NICU or special care admissions per subsequent pregnancy after completion of the program Parent/caregiver report

Not applicable

Secondary

Subsequent low birth weight newborn

Rate of subsequent low birth weight newborns per subsequent births after completion of the program Parent/caregiver report

Not applicable

Secondary
Nurse-Family Partnership (NFP)®
Show Study Effects Details
Outcome measure Effect Follow-up Timing Sample Sample Size Program Group Comparison Group Group Difference Effect size Statistical significance Outcome Type Notes
Number of infant and childhood deaths among firstborn children (birth–9 years)
FavorableUnfavorableNo Effect
9-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 627 mothers 4.50 per 1,000 = 4.50 20.08 per 1,000 = 20.08 OR = 0.22 Not available Not statistically significant,
p = 0.80
Secondary

footnote2

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the odds ratio.

Number of subsequent low birth weight newborns (0–9 years postpartum)
FavorableUnfavorableNo Effect
9-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 627 mothers Adjusted mean = 0.18 Adjusted mean = 0.27 Mean difference = -0.09 Not available Not statistically significant,
p = 0.07
Secondary

footnote4

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculation of incidence ratio.

Show Study Outcome Measure Summary
Outcome Measure Outcome Measure Description Collection method Properties Outcome Type Operations links

Number of infant and childhood deaths among firstborn children

Number of deaths that occurred among firstborn children over the period birth to age 9 Parent/caregiver report and review of National Death Index (NDI) records for parents/caregivers that were not interviewed.

Not applicable

Secondary

Number of subsequent low birth weight newborns

Number of low birth weight newborns the mother experienced since the birth of the study’s focal child Parent/caregiver report

Not applicable

Secondary
Nurse-Family Partnership (NFP)®
Show Study Effects Details
Outcome measure Effect Follow-up Timing Sample Sample Size Program Group Comparison Group Group Difference Effect size Statistical significance Outcome Type
Subsequent low birth weight newborns
FavorableUnfavorableNo Effect
4-year follow-up Nurse home visitor and comparison (Denver) 424 mothers = 0.06 = 0.08 OR = 0.75 HomeVEE calculated = -0.17 Not statistically significant,
p = 0.45
Secondary
Subsequent special care admissions
FavorableUnfavorableNo Effect
4-year follow-up Nurse home visitor and comparison (Denver) 424 mothers = 0.06 = 0.08 OR = 0.66 HomeVEE calculated = -0.26 Not statistically significant,
p = 0.27
Secondary
Show Study Outcome Measure Summary
Outcome Measure Outcome Measure Description Collection method Properties Outcome Type Operations links

Subsequent NICU or special care admissions

Rate of subsequent NICU or special care admissions per subsequent pregnancy since the birth of the study’s focal child Parent/caregiver report

Not applicable

Secondary

Subsequent low birth weight newborns

Rate of subsequent low birth weight newborns per subsequent births since the birth of the study’s focal child Parent/caregiver report

Not applicable

Secondary
Nurse-Family Partnership (NFP)®
Show Study Effects Details
Outcome measure Effect Follow-up Timing Sample Sample Size Program Group Comparison Group Group Difference Effect size Statistical significance Outcome Type
Binge drinking
FavorableUnfavorableNo Effect
19-year follow-up Nurse visited during pregnancy and infancy and comparison (Elmira) 231 children %(adjusted) = 28.00 Adjusted mean % = 32.00 Difference = -0.03 HomeVEE calculated = -0.10 Not statistically significant, p > 0.05 Secondary
Binge drinking
FavorableUnfavorableNo Effect
19-year follow-up Nurse visited during pregnancy and comparison (Elmira) 219 children %(adjusted) = 36.00 Adjusted mean % = 32.00 Difference = 0.04 HomeVEE calculated = 0.11 Not statistically significant, p > 0.05 Secondary
Ever been pregnant/made a girl pregnant
FavorableUnfavorableNo Effect
19-year follow-up Nurse visited during pregnancy + infancy and comparison (Elmira) 231 children % (adjusted) = 32.40 Adjusted mean % = 31.60 Difference = 0.80 HomeVEE calculated = 0.02 Not statistically significant, p > 0.05 Secondary
Ever been pregnant/made a girl pregnant
FavorableUnfavorableNo Effect
19-year follow-up Nurse visited during pregnancy and comparison (Elmira) 219 children %(adjusted) = 32.40 Adjusted mean % = 30.90 Difference = 1.50 HomeVEE calculated = 0.04 Not statistically significant, p > 0.05 Secondary
Ever fathered a child/given birth
FavorableUnfavorableNo Effect
19-year follow-up Nurse visited during pregnancy + infancy and comparison (Elmira) 231 children %(adjusted) = 21.20 Adjusted mean % = 20.70 Difference = 0.50 HomeVEE calculated = 0.02 Not statistically significant, p > 0.05 Secondary
Ever fathered a child/given birth
FavorableUnfavorableNo Effect
19-year follow-up Nurse visited during pregnancy and comparison (Elmira) 219 children %(adjusted) = 18.10 Adjusted mean % = 20.70 Difference = -2.60 HomeVEE calculated = -0.10 Not statistically significant, p > 0.05 Secondary
Frequency of birth control use
FavorableUnfavorableNo Effect
19-year follow-up Nurse visited during pregnancy + infancy and comparison (Elmira) 231 children Adjusted mean = 4.70 Adjusted mean = 4.60 Mean difference = 0.10 Not available Not statistically significant, p > 0.05 Secondary
Frequency of birth control use
FavorableUnfavorableNo Effect
19-year follow-up Nurse visited during pregnancy and comparison (Elmira) 219 children Adjusted mean = 4.90 Adjusted mean = 4.60 Mean difference = 0.30 Not available Not statistically significant, p > 0.05 Secondary
Frequency of condom use
FavorableUnfavorableNo Effect
19-year follow-up Nurse visited during pregnancy + infancy and comparison (Elmira) 231 children Adjusted mean = 3.90 Adjusted mean = 3.30 Mean difference = 0.60 Not available Not statistically significant, p > 0.05 Secondary
Frequency of condom use
FavorableUnfavorableNo Effect
19-year follow-up Nurse visited during pregnancy and comparison (Elmira) 219 children Adjusted mean = 3.70 Adjusted mean = 3.30 Mean difference = 0.40 Not available Not statistically significant, p > 0.05 Secondary
Illicit drug use
FavorableUnfavorableNo Effect
19-year follow-up Nurse visited during pregnancy and infancy and comparison (Elmira) 231 children %(adjusted) = 49.00 Adjusted mean % = 52.00 Difference = -0.03 HomeVEE calculated = -0.08 Not statistically significant, p > 0.05 Secondary
Illicit drug use
FavorableUnfavorableNo Effect
19-year follow-up Nurse visited during pregnancy and comparison (Elmira) 219 children %(adjusted) = 53.00 Adjusted mean % = 52.00 Difference = 0.01 HomeVEE calculated = 0.02 Not statistically significant, p > 0.05 Secondary
Number of sex partners, past year
FavorableUnfavorableNo Effect
19-year follow-up Nurse visited during pregnancy + infancy and comparison (Elmira) 231 children Adjusted mean = 1.73 Adjusted mean = 1.55 Mean difference = 0.18 Not available Not statistically significant, p > 0.05 Secondary
Number of sex partners, past year
FavorableUnfavorableNo Effect
19-year follow-up Nurse visited during pregnancy and comparison (Elmira) 219 children Adjusted mean = 1.68 Adjusted mean = 1.55 Mean difference = 0.13 Not available Not statistically significant, p > 0.05 Secondary
Show Study Outcome Measure Summary
Outcome Measure Outcome Measure Description Collection method Properties Outcome Type Operations links

Ever been pregnant/made a girl pregnant

Percentage of youth that had become or made a girl pregnant or become a parent Adolescent report

Not applicable

Secondary

Ever fathered a child/given birth

Percentage of youth that had fathered a child or given birth Adolescent report

Not applicable

Secondary

Frequency of birth control use

A scale indicating the frequency of birth control use ranging from 1 (never) to 7(always) Adolescent report

Not applicable

Secondary

Frequency of condom use

A scale indicating the frequency of condom use ranging from 1 (never) to 7(always) Adolescent report

Not applicable

Secondary

Number of sex partners, past year

Count of the study child’s number of sexual partners during the 12 month period prior to the interview. Adolescent report

Not applicable

Secondary
Nurse-Family Partnership (NFP)®
Show Study Effects Details
Outcome measure Effect Follow-up Timing Sample Sample Size Program Group Comparison Group Group Difference Effect size Statistical significance Outcome Type Notes
Number of subsequent low birth weight newborns (< 2500 g)
FavorableUnfavorableNo Effect
3-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 646 mothers Mean = 0.12 Mean = 0.15 Mean difference = -0.03 Not available Not statistically significant,
p ≥ 0.05
Secondary

footnote1

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the log-incidence difference.

Number of subsequent neonatal intensive care unit or special care admissions
FavorableUnfavorableNo Effect
3-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 646 mothers Mean = 0.14 Mean = 0.20 Mean difference = -0.06 Not available Not statistically significant,
p ≥ 0.05
Secondary

footnote1

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the log-incidence difference.

,

footnote3

Submitted by user on Fri, 03/15/2019 - 14:29

Authors report the difference in this outcome to be statistically significant, p < 0.10, which is greater than the acceptable alpha for this review (&alpha; = 0.05).

Show Study Outcome Measure Summary
Outcome Measure Outcome Measure Description Collection method Properties Outcome Type Operations links

Number of subsequent NICU or special care admissions

Number of NICU or special care admissions episodes the mother experienced after the birth of the study’s focal child Parent/caregiver report

Not applicable

Secondary

Number of subsequent low birth weight newborns (< 2,500 g)

Number of low birth weight newborns the mother experienced after the birth of the study’s focal child Parent/caregiver report

Not applicable

Secondary
Nurse-Family Partnership (NFP)®
Show Study Effects Details
Outcome measure Effect Follow-up Timing Sample Sample Size Program Group Comparison Group Group Difference Effect size Statistical significance Outcome Type
Incidence of days of substance use in the past 30 days
FavorableUnfavorableNo Effect
12 years Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 578 children = 0.03 = 0.18 IR = 0.15 Not available Statistically significant, p < .05 Secondary
Number of substances used in the past 30 days
FavorableUnfavorableNo Effect
12 years Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 578 children = 0.02 = 0.08 IR = 0.06 Not available Statistically significant, p < .05 Secondary
Used cigarettes, alcohol, or marijuana in the past 30 days
FavorableUnfavorableNo Effect
12 years Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 578 children %(adjusted) = 1.70 Adjusted mean % = 5.10 OR = 0.31 HomeVEE calculated = -0.69 Statistically significant, p < .05 Secondary
Show Study Outcome Measure Summary
Outcome Measure Outcome Measure Description Collection method Properties Outcome Type Operations links

Incidence of days of substance use in the past 30 days

Count of days of substance use (theoretical range, 0-90) Interview

Not applicable

Secondary

Number of substances used in the past 30 days

Count of substances used in the past 30 days (0-3) Interview

Not applicable

Secondary

Used cigarettes, alcohol, or marijuana in the past 30 days

Whether cigarettes, alcohol, or marijuana in the past 30 days (yes or no) Interview

Not applicable

Secondary
Nurse-Family Partnership (NFP)®
Show Study Effects Details
Outcome measure Effect Follow-up Timing Sample Sample Size Program Group Comparison Group Group Difference Effect size Statistical significance Outcome Type Notes
5-minute Apgar
FavorableUnfavorableNo Effect
Birth Full, (Memphis) 1082 children Adjusted mean = 8.60 Adjusted mean = 8.70 Mean difference = -0.10 Not available Not statistically significant,
p > 0.05
Primary
Birth weight, grams
FavorableUnfavorableNo Effect
Birth Full (Memphis) 1082 children Adjusted mean = 3032.20 Adjusted mean = 3050.40 Mean difference = -18.20 Not available Not statistically significant,
p > 0.05
Primary
Breastfeeding attempted, percentage
FavorableUnfavorableNo Effect
2 years postnatal Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 671 children % (adjusted) = 26.00 Adjusted mean % = 16.00 OR = 1.90 HomeVEE calculated = 0.37 Statistically significant,
p < 0.01
Secondary

footnote6

Submitted by user on Fri, 03/15/2019 - 14:29

The odds ratio compares the nurse-visited group to the comparison.

Gestational age, weeks
FavorableUnfavorableNo Effect
Birth Full, (Memphis) 1082 children Adjusted mean = 39.00 Adjusted mean = 39.00 Mean difference = 0.00 Not available Not statistically significant,
p > 0.05
Primary
Immunizations up to date, percentage
FavorableUnfavorableNo Effect
2 years postnatal Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 671 children % (adjusted) = 70.00 Adjusted mean % = 68.00 OR = 1.10 HomeVEE calculated = 0.06 Not statistically significant,
p > 0.05
Primary

footnote6

Submitted by user on Fri, 03/15/2019 - 14:29

The odds ratio compares the nurse-visited group to the comparison.

Indicated preterm delivery (percentage)
FavorableUnfavorableNo Effect
Birth Full, (Memphis) 1082 children % (adjusted) = 3.00 Adjusted mean % = 3.00 OR = 1.00 HomeVEE calculated = 0.00 Not statistically significant,
p > 0.05
Primary

footnote2

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the odds ratio.

,

footnote6

Submitted by user on Fri, 03/15/2019 - 14:29

The odds ratio compares the nurse-visited group to the comparison.

Intrauterine growth restriction (percentage)
FavorableUnfavorableNo Effect
Birth Full, (Memphis) 1082 children % (adjusted) = 9.00 Adjusted mean % = 9.00 OR = 1.00 HomeVEE calculated = 0.00 Not statistically significant,
p > 0.05
Primary

footnote2

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the odds ratio.

,

footnote6

Submitted by user on Fri, 03/15/2019 - 14:29

The odds ratio compares the nurse-visited group to the comparison.

Low birth weight (percentage < 2500 g)
FavorableUnfavorableNo Effect
Birth Full, (Memphis) 1082 children % (adjusted) = 15.00 Adjusted mean % = 14.00 OR = 1.10 HomeVEE calculated = 0.05 Not statistically significant,
p > 0.05
Primary

footnote2

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the odds ratio.

,

footnote6

Submitted by user on Fri, 03/15/2019 - 14:29

The odds ratio compares the nurse-visited group to the comparison.

Number of well-child visits
FavorableUnfavorableNo Effect
2 years postnatal Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 671 children Adjusted mean = 4.60 Adjusted mean = 4.80 Mean difference = -0.20 Not available Not statistically significant,
p > 0.05
Primary
Preterm (less than 37 weeks, percentage)
FavorableUnfavorableNo Effect
Birth Full, (Memphis) 1082 children % (adjusted) = 11.00 Adjusted mean % = 13.00 OR = 0.80 HomeVEE calculated = -0.12 Not statistically significant,
p > 0.05
Primary

footnote2

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the odds ratio.

,

footnote6

Submitted by user on Fri, 03/15/2019 - 14:29

The odds ratio compares the nurse-visited group to the comparison.

Spontaneous preterm delivery, percentage
FavorableUnfavorableNo Effect
Birth Full, (Memphis) 1082 children % (adjusted) = 8.00 Adjusted mean % = 9.00 OR = 0.80 HomeVEE calculated = -0.08 Not statistically significant,
p > 0.05
Primary

footnote2

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the odds ratio.

,

footnote6

Submitted by user on Fri, 03/15/2019 - 14:29

The odds ratio compares the nurse-visited group to the comparison.

Show Study Outcome Measure Summary
Outcome Measure Outcome Measure Description Collection method Properties Outcome Type Operations links

Activity, pulse, grimace, appearance, and respiration (Apgar) score: 5-minute

The Apgar test was administered five minutes after the child’s birth. The test evaluates the newborn along five dimensions: (1) activity and muscle tone; (2) pulse and heart rate; (3) grimace response; (4) appearance and skin coloration; and (5) respiration, breathing rate, and effort. Each dimension is scored 0 to 2, with higher scores associated with better health. Review of medical records

Not applicable

Primary

Birth weight

The child’s recorded birth weight in grams Review of medical records

Not applicable

Primary

Breastfeeding attempted

Percentage of mothers who had attempted breastfeeding Parent/caregiver report

Not applicable

Secondary

Gestational age

Gestational age in days was estimated from the reported last menstrual period (LMP) and ultrasound scans performed before 26 weeks’ gestation. If LMP and ultrasound converged within 14 days, then LMP was used for estimating gestational age. When LMP and ultrasound differed by more than 14 days, ultrasound was used as the estimate. In cases where ultrasound was not performed before 26 weeks’ gestation, or LMP was not known, the record was reviewed by two independent clinicians who were unaware of treatment condition to determine the most reliable estimate of gestational age. Review of medical records

Not applicable

Primary

Immunizations up-to-date

Percentage of children whose immunizations were up-to-date at their 2nd birthday Review of medical records

Not applicable

Primary

Indicated preterm delivery

Percentage of children who had an indicated preterm birth performed for maternal or fetal complications Review of medical records

Not applicable

Primary

Intrauterine growth restriction

Percentage of children with a birth weight less than the 10th percentile for their gestational age Review of medical records

Not applicable

Primary

Low birth weight

Percentage of children with a birth weight below 2,500 grams Review of medical records

Not applicable

Primary

Number of well-child visits

Number of well-child visits the child received Review of medical records

Not applicable

Primary

Preterm

Percentage of children who were delivered at less than 37 weeks’ gestation Review of medical records

Not applicable

Primary

Spontaneous preterm delivery

Percentage of children who had a spontaneous preterm birth after preterm labor with or without premature rupture of the membranes Review of medical records

Not applicable

Primary
Nurse-Family Partnership (NFP)®
Show Study Effects Details
Outcome measure Effect Follow-up Timing Sample Sample Size Program Group Comparison Group Group Difference Effect size Statistical significance Outcome Type
Crying (mother-reported number of episodes last 2 weeks)
FavorableUnfavorableNo Effect
6 months Nurse visited during pregnancy and comparison (Elmira) 164 children Adjusted mean = 4.05 Adjusted mean = 3.93 Mean difference = 0.12 Not available Statistical significance not reported Secondary
Crying (mother-reported number of episodes last 2 weeks)
FavorableUnfavorableNo Effect
6 months Nurse visited during pregnancy + infancy and comparison (Elmira) 163 children Adjusted mean = 3.44 Adjusted mean = 3.93 Mean difference = -0.49 Not available Not statistically significant,
p > 0.05
Secondary
Mother- reported positive mood
FavorableUnfavorableNo Effect
6 months Nurse visited during pregnancy and comparison (Elmira) 199 children Adjusted mean = 2.34 Adjusted mean = 2.29 Mean difference = 0.05 Not available Statistical significance not reported Secondary
Mother-reported positive mood
FavorableUnfavorableNo Effect
6 months Nurse visited during pregnancy + infancy and comparison (Elmira) 209 children Adjusted mean = 2.40 Adjusted mean = 2.29 Mean difference = 0.11 Not available Statistically significant,
p < 0.05
Secondary
Night awake (mother-reported number of episodes last 2 weeks
FavorableUnfavorableNo Effect
6 months Nurse visited during pregnancy and comparison (Elmira) 164 children Adjusted mean = 3.25 Adjusted mean = 2.83 Mean difference = 0.42 Not available Statistical significance not reported Secondary
Night awake (mother-reported number of episodes last 2 weeks
FavorableUnfavorableNo Effect
6 months Nurse visited during pregnancy + infancy and comparison (Elmira) 163 children Adjusted mean = 2.69 Adjusted mean = 2.83 Mean difference = -0.14 Not available Not statistically significant,
p > 0.05
Secondary
Number of emergency room visits (first year of life)
FavorableUnfavorableNo Effect
1-year follow-up Nurse visited during pregnancy and comparison (Elmira) 205 children Adjusted mean = 1.12 Adjusted mean = 1.02 Mean difference = 0.10 Not available Statistical significance not reported Primary
Number of emergency room visits (first year of life)
FavorableUnfavorableNo Effect
1-year follow-up Nurse visited during pregnancy + infancy and comparison (Elmira) 223 children Adjusted mean = 0.74 Adjusted mean = 1.02 Mean difference = -0.28 Not available Statistically significant,
p < 0.05
Primary
Number of emergency room visits (second year of life)
FavorableUnfavorableNo Effect
2-year follow-up Nurse visited during pregnancy and comparison (Elmira) 185 children Adjusted mean = 1.04 Adjusted mean = 1.09 Mean difference = -0.05 Not available Statistical significance not reported Primary
Number of emergency room visits (second year of life)
FavorableUnfavorableNo Effect
2-year follow-up Nurse visited during pregnancy + infancy and comparison (Elmira) 196 children Adjusted mean = 0.74 Adjusted mean = 1.09 Mean difference = -0.35 Not available Statistically significant,
p < 0.01
Primary
Resist eating (mother-reported number of episodes last 2 weeks)
FavorableUnfavorableNo Effect
6 months Nurse visited during pregnancy and comparison (Elmira) 164 children Adjusted mean = 2.01 Adjusted mean = 1.72 Mean difference = 0.29 Not available Statistical significance not reported Secondary
Resist eating (mother-reported number of episodes last 2 weeks)
FavorableUnfavorableNo Effect
6 months Nurse visited during pregnancy + infancy and comparison (Elmira) 163 children Adjusted mean = 2.29 Adjusted mean = 1.72 Mean difference = 0.57 Not available Statistically significant,
p < 0.01
Secondary
Show Study Outcome Measure Summary
Outcome Measure Outcome Measure Description Collection method Properties Outcome Type Operations links

Crying

Number of infant crying episodes in the last 2 weeks Parent/caregiver report

Not applicable

Secondary

Mother-reported positive mood

A measure of the extent to which the child had a happy, positive, and content disposition Parent/caregiver report

Not applicable

Secondary

Night awake

Number of times that most of the night was spent awake in the last 2 weeks Parent/caregiver report

Not applicable

Secondary

Number of emergency room visits

Total number of times the infant was seen in the emergency room Review of medical records

Not applicable

Primary

Resist eating

Number of times the infant resisted eating in the last 2 weeks Parent/caregiver report

Not applicable

Secondary
Nurse-Family Partnership (NFP)®
Show Study Effects Details
Outcome measure Effect Follow-up Timing Sample Sample Size Program Group Comparison Group Group Difference Effect size Statistical significance Outcome Type Notes
Number of child behavioral/parental coping problems in physician record (25 to 50 months)
FavorableUnfavorableNo Effect
50 months Nurse visited during pregnancy and comparison (Elmira) 209 mothers Adjusted mean = 0.43 Adjusted mean = 0.71 Mean difference = -0.28 Not available Statistical significance not reported Primary
Number of child behavioral/parental coping problems in physician record (25 to 50 months)
FavorableUnfavorableNo Effect
50 months Nurse visited during pregnancy + infancy and comparison (Elmira) 221 mothers Adjusted mean = 0.39 Adjusted mean = 0.71 Mean difference = -0.32 Not available Statistically significant,
p ≤ .01
Primary

footnote1

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the log-incidence difference.

Number of days hospitalized (25 to 50 months)
FavorableUnfavorableNo Effect
50 months Nurse visited during pregnancy and comparison (Elmira) 209 children Adjusted mean = 0.43 Adjusted mean = 0.31 Mean difference = 0.12 Not available Statistical significance not reported Primary
Number of days hospitalized (25 to 50 months)
FavorableUnfavorableNo Effect
50 months Nurse visited during pregnancy + infancy and comparison (Elmira) 221 children Adjusted mean = 0.49 Adjusted mean = 0.31 Mean difference = 0.18 Not available Statistically significant,
p ≤ 0.05
Primary

footnote1

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the log-incidence difference.

Number of emergency department visits (25 to 50 months)
FavorableUnfavorableNo Effect
50 months Nurse visited during pregnancy and comparison (Elmira) 209 children Adjusted mean = 1.24 Adjusted mean = 1.53 Mean difference = -0.29 Not available Statistical significance not reported Primary
Number of emergency department visits (25 to 50 months)
FavorableUnfavorableNo Effect
50 months Nurse visited during pregnancy + infancy and comparison (Elmira) 221 children Adjusted mean = 1.00 Adjusted mean = 1.53 Mean difference = -0.53 Not available Statistically significant,
p ≤ .01
Primary

footnote1

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the log-incidence difference.

Number of hospital admissions (25 to 50 months)
FavorableUnfavorableNo Effect
50 months Nurse visited during pregnancy and comparison (Elmira) 209 children Adjusted mean = 0.11 Adjusted mean = 0.11 Mean difference = 0.00 Not available Statistical significance not reported Primary
Number of hospital admissions (25 to 50 months)
FavorableUnfavorableNo Effect
50 months Nurse visited during pregnancy + infancy and comparison (Elmira) 221 children Adjusted mean = 0.14 Adjusted mean = 0.11 Mean difference = 0.03 Not available Not statistically significant,
p > 0.05
Primary

footnote1

Submitted by user on Fri, 03/15/2019 - 14:29

Statistical significance reported on authors’ calculations of the log-incidence difference.

Number of scheduled health supervision visits (25 to 50 months)
FavorableUnfavorableNo Effect
50 months Nurse visited during pregnancy and comparison (Elmira) 209 children Adjusted mean = 1.27 Adjusted mean = 1.56 Mean difference = -0.29 Not available Statistical significance not reported Primary
Number of scheduled health supervision visits (25 to 50 months)
FavorableUnfavorableNo Effect
50 months Nurse visited during pregnancy + infancy and comparison (Elmira) 221 children Adjusted mean = 1.26 Adjusted mean = 1.56 Mean difference = -0.30 Not available Not statistically significant,
p > 0.05
Primary
Number of scheduled health supervision visits with problems (25 to 50 months)
FavorableUnfavorableNo Effect
50 months Nurse visited during pregnancy and comparison (Elmira) 209 children Adjusted mean = 5.18 Adjusted mean = 6.72 Mean difference = -1.54 Not available Statistical significance not reported Primary
Number of scheduled health supervision visits with problems (25 to 50 months)
FavorableUnfavorableNo Effect
50 months Nurse visited during pregnancy + infancy and comparison (Elmira) 221 children Adjusted mean = 6.24 Adjusted mean = 6.72 Mean difference = -0.48 Not available Not statistically significant,
p > 0.05
Primary
Show Study Outcome Measure Summary
Outcome Measure Outcome Measure Description Collection method Properties Outcome Type Operations links

Number of child behavioral/parental coping problems in physician record

Number of child behavioral and parental coping problems noted in the physician’s record Review of medical records

Inter-rater agreement for the abstraction of diagnostic codes in the medical records was 90%.

Primary

Number of days hospitalized

Number of days the child was hospitalized Review of medical records

Inter-rater agreement for the abstraction of diagnostic codes in the medical records was 90%.

Primary

Number of emergency department visits

Total number of emergency department encounters Review of medical records

Inter-rater agreement for the abstraction of diagnostic codes in the medical records was 90%.

Primary

Number of hospital admissions

Number of child hospitalizations Review of medical records

Inter-rater agreement for the abstraction of diagnostic codes in the medical records was 90%.

Primary

Number of scheduled health supervision visits

Number of scheduled health supervision visits for the child Review of medical records

Inter-rater agreement for the abstraction of diagnostic codes in the medical records was 90%.

Primary

Number of scheduled health supervision visits with problems

Number of health supervision visits at which separate illnesses were detected in the child. This included initial sick visits for an illness, as well as well-child visits at which health problems were identified. Review of medical records

Inter-rater agreement for the abstraction of diagnostic codes in the medical records was 90%.

Primary

Outcomes Rated Moderate

Nurse-Family Partnership (NFP)®
Show Study Effects Details
Outcome measure Effect Follow-up Timing Sample Sample Size Program Group Comparison Group Group Difference Effect size Statistical significance Outcome Type Notes

Low birthweight of the second child

FavorableUnfavorableNo Effect

18 years

Nurse Family Partnership vs. comparison, Memphis New Mother's Study 1990-1991, mothers with second child

512 children Not reported Not reported Odds ratio = 0.51 Study reported = -0.41

Statistically significant, p <0.05

Primary ,

Effect size based on study OR

Submitted by barbara on Fri, 04/12/2019 - 18:55

HomVEE calculated the effect size based on the study-reported odds ratio.

Preterm birth of the second child

FavorableUnfavorableNo Effect

18 years

Nurse Family Partnership vs. comparison, Memphis New Mother's Study 1990-1991, mothers with second child

470 children Not reported Not reported Odds ratio = 1.07 Study reported = 0.04

Not statistically significant, p >.05

Primary ,

Effect size based on study OR

Submitted by barbara on Fri, 04/12/2019 - 18:55

HomVEE calculated the effect size based on the study-reported odds ratio.

Show Study Outcome Measure Summary
Outcome Measure Outcome Measure Description Collection method Properties Outcome Type Operations links

Low birthweight of the second child

Likelihood of second born child having a birthweight below 2,500 grams

Review of medical records

Not applicable

Primary

Preterm birth of the second child

Likelihood of second child being born before the 37th week of gestation

Review of medical records

Not applicable

Primary
Nurse-Family Partnership (NFP)®
Show Study Effects Details
Outcome measure Effect Follow-up Timing Sample Sample Size Program Group Comparison Group Group Difference Effect size Statistical significance Outcome Type
Birth weight (grams)
FavorableUnfavorableNo Effect
Birth NFP-trained nurse visitors and comparison nurse visitors 156 children Mean = 3.00 Mean = 3.00 Mean difference = 164.26 HomeVEE calculated = 0.29 Not reported Secondary
Gestational age (months)
FavorableUnfavorableNo Effect
Birth NFP-trained nurse visitors and comparison nurse visitors 154 children Mean = 38.88 Mean = 38.92 Mean difference = -0.04 HomeVEE calculated = -0.02 Not reported Secondary
Show Study Outcome Measure Summary
Outcome Measure Outcome Measure Description Collection method Properties Outcome Type Operations links

Birth weight

The child’s birth weight in grams Parent/caregiver report

Not applicable

Secondary

Gestational age

The child’s gestational age at birth in weeks Parent/caregiver report

Not applicable

Secondary
Nurse-Family Partnership (NFP)®
Show Study Effects Details
Outcome measure Effect Follow-up Timing Sample Sample Size Program Group Comparison Group Group Difference Effect size Statistical significance Outcome Type Notes
20 year child mortality rate - all causes (Nurse home visits during pregnancy and infancy vs. developmental screening comparison)
FavorableUnfavorableNo Effect
20 years Nurse home visits during pregnancy and infancy vs. developmental screening comparison (Memphis) 708 mother/child dyads Unadjusted mean = 0.01 Unadjusted mean = 0.03 Mean difference = -0.02 HomeVEE calculated = -0.68 Not statistically significant, p = 0.11 Primary

footnote162

Submitted by user on Fri, 03/15/2019 - 14:29

Negative value is favorable to the intervention.

20 year child mortality rate - preventable cause (Nurse home visits during pregnancy and infancy vs. developmental screening comparison)
FavorableUnfavorableNo Effect
20 years Nurse home visits during pregnancy and infancy vs. developmental screening comparison (Memphis) 708 mother/child dyads Unadjusted mean = 0.00 Unadjusted mean = 0.02 Mean difference = -0.02 Not available Statistically significant, p = 0.04 Primary

footnote162

Submitted by user on Fri, 03/15/2019 - 14:29

Negative value is favorable to the intervention.

Show Study Outcome Measure Summary
Outcome Measure Outcome Measure Description Collection method Properties Outcome Type Operations links

20 year child mortality rate - all causes (Nurse home visits during pregnancy and infancy vs. developmental screening comparison)

Percentage of children dying from any cause Administrative records (National Death Index)

Not applicable

Primary

20 year child mortality rate - preventable cause (Nurse home visits during pregnancy and infancy vs. developmental screening comparison)

Percentage of children dying from preventable causes (SIDS, unintentional injury, homicide) Administrative records (National Death Index)

Not applicable

Primary
NFP with Paraprofessional Home Visitors
Show Study Effects Details
Outcome measure Effect Follow-up Timing Sample Sample Size Program Group Comparison Group Group Difference Effect size Statistical significance Outcome Type
Subsequent low birth weight newborns
FavorableUnfavorableNo Effect
4-year follow-up Paraprofessional. home visitor and comparison (Denver) 431 mothers = 0.03 = 0.08 OR = 0.34 HomeVEE calculated = -0.64 Statistically significant,
p = 0.03
Secondary
Subsequent special care admissions
FavorableUnfavorableNo Effect
4-year follow-up Paraprofessional home visitor and comparison (Denver) 431 mothers = 0.05 = 0.08 OR = 0.54 HomeVEE calculated = -0.38 Not statistically significant,
p = 0.13
Secondary
Show Study Outcome Measure Summary
NFP with Paraprofessional Home Visitors
Show Study Effects Details
Outcome measure Effect Follow-up Timing Sample Sample Size Program Group Comparison Group Group Difference Effect size Statistical significance Outcome Type
Subsequent low birth weight newborns
FavorableUnfavorableNo Effect
4-year follow-up Paraprofessional. home visitor and comparison (Denver) 431 mothers = 0.03 = 0.08 OR = 0.34 HomeVEE calculated = -0.64 Statistically significant,
p = 0.03
Secondary
Subsequent special care admissions
FavorableUnfavorableNo Effect
4-year follow-up Paraprofessional home visitor and comparison (Denver) 431 mothers = 0.05 = 0.08 OR = 0.54 HomeVEE calculated = -0.38 Not statistically significant,
p = 0.13
Secondary
Show Study Outcome Measure Summary
NFP with Paraprofessional Home Visitors
Show Study Effects Details
Outcome measure Effect Follow-up Timing Sample Sample Size Program Group Comparison Group Group Difference Effect size Statistical significance Outcome Type
Subsequent low birth weight newborns
FavorableUnfavorableNo Effect
4-year follow-up Paraprofessional. home visitor and comparison (Denver) 431 mothers = 0.03 = 0.08 OR = 0.34 HomeVEE calculated = -0.64 Statistically significant,
p = 0.03
Secondary
Subsequent special care admissions
FavorableUnfavorableNo Effect
4-year follow-up Paraprofessional home visitor and comparison (Denver) 431 mothers = 0.05 = 0.08 OR = 0.54 HomeVEE calculated = -0.38 Not statistically significant,
p = 0.13
Secondary
Show Study Outcome Measure Summary
NFP with Paraprofessional Home Visitors
Show Study Effects Details
Outcome measure Effect Follow-up Timing Sample Sample Size Program Group Comparison Group Group Difference Effect size Statistical significance Outcome Type
Subsequent low birth weight newborns
FavorableUnfavorableNo Effect
4-year follow-up Paraprofessional. home visitor and comparison (Denver) 431 mothers = 0.03 = 0.08 OR = 0.34 HomeVEE calculated = -0.64 Statistically significant,
p = 0.03
Secondary
Subsequent special care admissions
FavorableUnfavorableNo Effect
4-year follow-up Paraprofessional home visitor and comparison (Denver) 431 mothers = 0.05 = 0.08 OR = 0.54 HomeVEE calculated = -0.38 Not statistically significant,
p = 0.13
Secondary
Show Study Outcome Measure Summary
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