Nurse-Family Partnership (NFP)® Meets HHS Criteria

Model effectiveness research report last updated: 2024

Effects shown in research

Maternal health

Findings rated high

Nurse-Family Partnership (NFP)®
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes

Mental health - Anxiety: Mental Health Inventory (MHI)

FavorableUnfavorable or ambiguousNo Effect

15 years

Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample

300 mothers Unadjusted mean = 2.56 Unadjusted mean = 2.56 MD = 0.00 HomVEE calculated = 0.00

Not statistically significant, p = 1.00

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Mental health - Depression: Mental Health Inventory (MHI)

FavorableUnfavorable or ambiguousNo Effect

15 years

Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample

300 mothers Unadjusted mean = 2.01 Unadjusted mean = 2.02 MD = -0.01 HomVEE calculated = -0.01

Not statistically significant, p = 0.95

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Mental health - Emotional stability: Mental Health Inventory (MHI)

FavorableUnfavorable or ambiguousNo Effect

15 years

Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample

300 mothers Unadjusted mean = 3.75 Unadjusted mean = 3.74 MD = 0.01 HomVEE calculated = 0.02

Not statistically significant, p = 0.90

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Mental health - Positive well-being: Mental Health Inventory (MHI)

FavorableUnfavorable or ambiguousNo Effect

15 years

Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample

300 mothers Unadjusted mean = 3.78 Unadjusted mean = 3.79 MD = -0.01 HomVEE calculated = -0.02

Not statistically significant, p = 0.90

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Nurse-Family Partnership (NFP)®
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes
Anxiety (MHI), 24 months postpartum, standardized
FavorableUnfavorable or ambiguousNo Effect
2 years postpartum Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 671 mothers Adjusted mean = 99.10 Adjusted mean = 100.30 Mean difference = -1.20 Not available Not statistically significant, p ≥ 0.05
Depression (MHI), 24 months postpartum, standardized
FavorableUnfavorable or ambiguousNo Effect
2 years postpartum Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 671 mothers Adjusted mean = 99.50 Adjusted mean = 100.10 Mean difference = -0.06 Not available Not statistically significant, p ≥ 0.05
Diastolic blood pressure
FavorableUnfavorable or ambiguousNo Effect
36th week of pregnancy Full (Memphis) 916 mothers Adjusted mean = 66.80 Adjusted mean = 67.50 Mean difference = -0.70 Not available Not statistically significant, p ≥ 0.05
Submitted by user on
This mean difference, calculated by HomVEE, is within |0.01| of the difference reported by the authors, with the discrepancy likely due to rounding error.
Gestational weight gain
FavorableUnfavorable or ambiguousNo Effect
36th week of pregnancy Full (Memphis) 916 mothers Adjusted mean = 14.60 Adjusted mean = 14.90 Mean difference = -0.30 Not available Not statistically significant, p ≥ 0.05
Number of Gardnerella infections
FavorableUnfavorable or ambiguousNo Effect
36th week of pregnancy Full (Memphis) 916 mothers Adjusted mean = 0.06 Adjusted mean = 0.07 Mean difference = -0.01 Not available Not statistically significant, p ≥ 0.05
Submitted by user on
Statistical significance reported on authors’ calculations of the log-incidence difference.
Number of hospitalizations during pregnancy
FavorableUnfavorable or ambiguousNo Effect
36th week of pregnancy Full (Memphis) 916 mothers Adjusted mean = 0.15 Adjusted mean = 0.13 Mean difference = 0.02 Not available Not statistically significant, p ≥ 0.05
Submitted by user on
Statistical significance reported on authors’ calculations of the log-incidence difference.
Number of sexually transmitted diseases
FavorableUnfavorable or ambiguousNo Effect
36th week of pregnancy Full (Memphis) 916 mothers Adjusted mean = 0.22 Adjusted mean = 0.21 Mean difference = 0.01 Not available Not statistically significant, p ≥ 0.05
Submitted by user on
Statistical significance reported on authors’ calculations of the log-incidence difference.
Number of yeast infections
FavorableUnfavorable or ambiguousNo Effect
36th week of pregnancy Full (Memphis) 916 mothers Adjusted mean = 0.14 Adjusted mean = 0.19 Mean difference = -0.05 Not available Statistically significant,
p ≤ 0.05
Submitted by user on
Statistical significance reported on authors’ calculations of the log-incidence difference.
Obstetrical evaluation visits (total)
FavorableUnfavorable or ambiguousNo Effect
36th week of pregnancy Full (Memphis) 916 mothers Adjusted mean = 2.80 Adjusted mean = 2.80 Mean difference = 0.00 Not available Not statistically significant, p ≥ 0.05
Submitted by user on
This mean difference, calculated by HomVEE, is within |0.01| of the difference reported by the authors, with the discrepancy likely due to rounding error.
Pearlin Mastery, 24 months postpartum, standardized
FavorableUnfavorable or ambiguousNo Effect
2 years postpartum Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 671 mothers Adjusted mean = 101.60 Adjusted mean = 99.40 Mean difference = 2.20 Not available Statistically significant,
p < 0.01
Pregnancy-induced hypertension (percentage)
FavorableUnfavorable or ambiguousNo Effect
36th week of pregnancy Full (Memphis) 916 mothers % (adjusted) = 13.00 Adjusted mean % = 20.00 OR = 0.60 HomVEE calculated = -0.31 Statistically significant,
p ≤ 0.01
Submitted by user on
Statistical significance reported on authors’ calculations of the odds ratio.
Submitted by user on
The odds ratio compares the nurse-visited group to the comparison.
Spontaneous abortion, 0–24 months postpartum (percentage)
FavorableUnfavorable or ambiguousNo Effect
2 years postpartum Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 671 mothers % (adjusted) = 5.00 Adjusted mean % = 3.00 OR = 1.50 HomVEE calculated = 0.32 Not statistically significant, p ≥ 0.05
Submitted by user on
The odds ratio compares the nurse-visited group to the comparison.
Standard prenatal care visits (total)
FavorableUnfavorable or ambiguousNo Effect
36th week of pregnancy Full (Memphis) 916 mothers Adjusted mean = 6.20 Adjusted mean = 6.50 Mean difference = -0.30 Not available Not statistically significant, p ≥ 0.05
Subsequent live birth, 0–24 months postpartum (percentage)
FavorableUnfavorable or ambiguousNo Effect
2 years postpartum Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 671 mothers % (adjusted) = 22.00 Adjusted mean % = 31.00 OR = 0.60 HomVEE calculated = -0.28 Statistically significant,
p < 0.01
Submitted by user on
Statistical significance reported on authors’ calculations of the odds ratio.
Submitted by user on
The odds ratio compares the nurse-visited group to the comparison.
Subsequent pregnancy, 0-24 months postpartum (percentage)
FavorableUnfavorable or ambiguousNo Effect
2 years postpartum Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 671 mothers % (adjusted) = 36.00 Adjusted mean % = 47.00 OR = 0.60 HomVEE calculated = -0.28 Statistically significant,
p < 0.01
Submitted by user on
Statistical significance reported on authors’ calculations of the odds ratio.
Submitted by user on
The odds ratio compares the nurse-visited group to the comparison.
Systolic blood pressure
FavorableUnfavorable or ambiguousNo Effect
36th week of pregnancy Full (Memphis) 916 mothers Adjusted mean = 111.70 Adjusted mean = 112.60 Mean difference = -0.90 Not available Not statistically significant, p ≥ 0.05
Therapeutic abortion, 0–24 months postpartum (percentage)
FavorableUnfavorable or ambiguousNo Effect
2 years postpartum Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 671 mothers % (adjusted) = 2.00 Adjusted mean % = 4.00 OR = 0.50 HomVEE calculated = -0.43 Not statistically significant, p ≥ 0.05
Submitted by user on
The odds ratio compares the nurse-visited group to the comparison.
Nurse-Family Partnership (NFP)®
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes
Number of months between birth or first and second child
FavorableUnfavorable or ambiguousNo Effect
3-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 646 mothers Adjusted mean = 30.25 Adjusted mean = 26.60 Mean difference = 3.65 Not available Statistically significant,
p ≤ 0.01
Number of subsequent live births
FavorableUnfavorable or ambiguousNo Effect
3-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 646 mothers Adjusted mean = 0.85 Adjusted mean = 0.96 Mean difference = -0.11 Not available Not statistically significant,
p ≥ 0.05
Number of subsequent pregnancies
FavorableUnfavorable or ambiguousNo Effect
3-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 646 mothers Adjusted mean = 1.15 Adjusted mean = 1.34 Mean difference = -0.19 Not available Statistically significant,
p < 0.05
Number of subsequent pregnancies with short intervals (< 6 months from previous delivery or termination)
FavorableUnfavorable or ambiguousNo Effect
3-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 646 mothers Adjusted mean = 0.22 Adjusted mean = 0.32 Mean difference = -0.10 Not available Statistically significant,
p < 0.05
Submitted by user on
Statistical significance reported on authors’ calculations of the log-incidence difference.
Number of subsequent spontaneous abortions
FavorableUnfavorable or ambiguousNo Effect
3-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 646 mothers Adjusted mean = 0.10 Adjusted mean = 0.12 Mean difference = -0.12 Not available Not statistically significant,
p ≥ 0.05
Submitted by user on
Statistical significance reported on authors’ calculations of the log-incidence difference.
Number of subsequent still births
FavorableUnfavorable or ambiguousNo Effect
3-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 646 mothers Adjusted mean = 0.01 Adjusted mean = 0.02 Mean difference = -0.01 Not available Not statistically significant
p ≥ 0.05
Submitted by user on
Statistical significance reported on authors’ calculations of the log-incidence difference.
Number of subsequent therapeutic abortions
FavorableUnfavorable or ambiguousNo Effect
3-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 646 mothers Adjusted mean = 0.05 Adjusted mean = 0.10 Mean difference = -0.05 Not available Not statistically significant,
p ≥ 0.05
Submitted by user on
Authors report the difference in this outcome to be statistically significant, p < 0.10, which is greater than the acceptable alpha for this review (α = 0.05).
Nurse-Family Partnership (NFP)®
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes

Current smoker

FavorableUnfavorable or ambiguousNo Effect

15-month follow-up

NFP vs. Resource referral RCT (MIHOPE), 2012-2015, United States,full sample

907 mothers Adjusted proportion = 0.13 Adjusted proportion = 0.12 Difference = 0.00 Study reported = 0.02

Not statistically significant, p ≥ 0.05

Submitted by user on

Negative effect is favorable to the intervention.

The statistical significance after adjusting for multiple comparisons is reported; precise p-values are not available.

Parenting Stress Index - Short Form (PSI-SF), parent-child dysfunctional interaction

FavorableUnfavorable or ambiguousNo Effect

15-month follow-up

NFP vs. Resource referral RCT (MIHOPE), 2012-2015, United States,full sample

914 mothers Adjusted mean = 10.30 Adjusted mean = 11.10 Difference = -0.80 Not available

Statistically significant, p < 0.05

Submitted by user on

Negative effect is favorable to the intervention.

The statistical significance after adjusting for multiple comparisons is reported; precise p-values are not available. The study reported this finding was statistically significant (p = 0.001) prior to a multiple comparisons adjustment, and remained significant after the adjustment.

Parenting Stress Index - Short Form (PSI-SF), parental distress

FavorableUnfavorable or ambiguousNo Effect

15-month follow-up

NFP vs. Resource referral RCT (MIHOPE), 2012-2015, United States,full sample

917 mothers Adjusted mean = 11.10 Adjusted mean = 11.40 Difference = -0.30 Not available

Not statistically significant, p ≥ 0.05

Submitted by user on

Negative effect is favorable to the intervention.

HomVEE calculated the adjusted intervention group mean by adding the reported adjusted comparison group mean to the reported estimated effect. The statistical significance after adjusting for multiple comparisons is reported; precise p-values are not available.

Received any behavioral health services

FavorableUnfavorable or ambiguousNo Effect

15-month follow-up

NFP vs. Resource referral RCT (MIHOPE), 2012-2015, United States,full sample

906 mothers Adjusted proportion = 0.05 Adjusted proportion = 0.04 Difference = 0.00 Study reported = 0.06

Not statistically significant, p ≥ 0.05

The statistical significance after adjusting for multiple comparisons is reported; precise p-values are not available.

Substance use during the past three months

FavorableUnfavorable or ambiguousNo Effect

15-month follow-up

NFP vs. Resource referral RCT (MIHOPE), 2012-2015, United States,full sample

908 mothers Adjusted proportion = 0.17 Adjusted proportion = 0.12 Difference = 0.05 Study reported = 0.27

Not statistically significant, p ≥ 0.05

Submitted by user on

Negative effect is favorable to the intervention.

The statistical significance after adjusting for multiple comparisons is reported; precise p-values are not available. The study reported this finding was statistically significant (p = 0.02) prior to a multiple comparisons adjustment.

Nurse-Family Partnership (NFP)®
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes

Any smoking during third trimester (%)

FavorableUnfavorable or ambiguousNo Effect

Birth

NFP vs. Resource referral RCT (MIHOPE-Strong Start), 2012-2015, United States, full sample

1404 mothers Not reported Not reported Difference = 0.01 Not available

Not statistically significant, p= 0.23

Submitted by user on

Negative effect is favorable to the intervention.

Nurse-Family Partnership (NFP)®
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes

Cesarean delivery

FavorableUnfavorable or ambiguousNo Effect

Child's birth

NFP vs. usual care RCT, South Carolina 2016-2021, full sample

4932 mothers Adjusted proportion = 0.31 Cases Adjusted proportion = 0.33 Cases Mean difference = -0.02 Study reported = -0.06

Not statistically significant, p= ≥0.05

Submitted by user on

Negative effect is favorable to the intervention.

Severe maternal morbidity

FavorableUnfavorable or ambiguousNo Effect

Child's birth

NFP vs. usual care RCT, South Carolina 2016-2021, full sample

5158 mothers Adjusted proportion = 0.02 Cases Adjusted proportion = 0.01 Cases Mean difference = 0.00 Study reported = 0.13

Not statistically significant, p= ≥0.05

Submitted by user on

Negative effect is favorable to the intervention.

Nurse-Family Partnership (NFP)®
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance

New pregnancy after study entry, % (fixed effect random slope analysis)

FavorableUnfavorable or ambiguousNo Effect

15 months old

NFP vs. Resource referral RCT (MIHOPE), 2012-2015, United States, full sample

903 mothers Not reported Not reported Difference = 0.00 Not available

Not statistically significant, p= 0.97

New pregnancy after study entry, % (restricted maximum likelihood analysis)

FavorableUnfavorable or ambiguousNo Effect

15 months old

NFP vs. Resource referral RCT (MIHOPE), 2012-2015, United States, full sample

903 mothers Not reported Not reported Difference = 0.00 Not available

Not statistically significant, p= 0.98

New pregnancy after study entry, % (split-sample analysis)

FavorableUnfavorable or ambiguousNo Effect

15 months old

NFP vs. Resource referral RCT (MIHOPE), 2012-2015, United States, full sample

903 mothers Not reported Not reported Difference = 0.02 HomVEE calculated = 0.09

Not statistically significant, p= 0.40

Nurse-Family Partnership (NFP)®
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes
Incidence of substance use impairments
FavorableUnfavorable or ambiguousNo Effect
15-year follow-up Nurse visited during pregnancy + infancy and comparison (Elmira) 245 mothers Adjusted mean = 0.34 Adjusted mean = 0.43 Mean difference = -0.09 Not available Not statistically significant,
p ≥ 0.05
Submitted by user on
Statistical significance reported on authors’ calculations of the log-incidence difference.
Months between birth of first and second child
FavorableUnfavorable or ambiguousNo Effect
15-year follow-up Nurse visited during pregnancy and comparison (Elmira) 227 mothers Adjusted mean = 39.80 Adjusted mean = 37.30 Mean difference = 2.50 Not available Statistical significance not reported
Months between birth of first and second child
FavorableUnfavorable or ambiguousNo Effect
15-year follow-up Nurse visited during pregnancy + infancy and comparison (Elmira) 245 mothers Adjusted mean = 41.70 Adjusted mean = 37.30 Mean difference = 4.40 Not available Not statistically significant,
p ≥ 0.05
Subsequent births
FavorableUnfavorable or ambiguousNo Effect
15-year follow-up Nurse visited during pregnancy and comparison (Elmira) 227 mothers Adjusted mean = 1.40 Adjusted mean = 1.60 Mean difference = -0.20 Not available Statistical significance not reported
Subsequent births
FavorableUnfavorable or ambiguousNo Effect
15-year follow-up Nurse visited during pregnancy + infancy and comparison (Elmira) 245 mothers Adjusted mean = 1.30 Adjusted mean = 1.60 Mean difference = -0.30 Not available Not statistically significant,
p ≥ 0.05
Subsequent pregnancies
FavorableUnfavorable or ambiguousNo Effect
15-year follow-up Nurse visited during pregnancy and comparison (Elmira) 227 mothers Adjusted mean = 1.90 Adjusted mean = 2.10 Mean difference = -0.20 Not available Statistical significance not reported
Subsequent pregnancies
FavorableUnfavorable or ambiguousNo Effect
15-year follow-up Nurse visited during pregnancy + infancy and comparison (Elmira) 245 mothers Adjusted mean = 1.70 Adjusted mean = 2.10 Mean difference = -0.40 Not available Not statistically significant,
p ≥ 0.05
Substance use impairments since birth of first child
FavorableUnfavorable or ambiguousNo Effect
15-year follow-up Nurse visited during pregnancy and comparison (Elmira) 227 mothers Adjusted mean = 0.45 Adjusted mean = 0.43 Mean difference = 0.02 Not available Statistical significance not reported
Nurse-Family Partnership (NFP)®
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes
Number of births including first born (0–46 months postpartum)
FavorableUnfavorable or ambiguousNo Effect
46 months, postpartum Nurse visited during pregnancy and comparison (Elmira) 203 mothers Adjusted mean = 1.77 Adjusted mean = 1.85 Mean difference = -0.08 Not available Statistical significance not reported
Number of births including first born (0–46 months postpartum)
FavorableUnfavorable or ambiguousNo Effect
46 months, postpartum Nurse visited during pregnancy + infancy and comparison (Elmira) 216 mothers Adjusted mean = 1.65 Adjusted mean = 1.85 Mean difference = -0.20 Not available Not statistically significant, p ≥ 0.05
Submitted by user on
Statistical significance reported on authors’ calculations of the log-incidence difference.
Number of months between first and second child (0–46 months postpartum)
FavorableUnfavorable or ambiguousNo Effect
46 months, postpartum Nurse visited during pregnancy and comparison (Elmira) 203 mothers Adjusted mean = 41.58 Adjusted mean = 37.11 Mean difference = 4.47 Not available Statistical significance not reported
Number of months between first and second child (0–46 months postpartum)
FavorableUnfavorable or ambiguousNo Effect
46 months, postpartum Nurse visited during pregnancy + infancy and comparison (Elmira) 216 mothers Adjusted mean = 40.76 Adjusted mean = 37.11 Mean difference = 3.65 Not available Not statistically significant, p ≥ 0.05
Submitted by user on
Statistical significance reported on authors’ calculations of the log-incidence difference.
Number of pregnancies (0–22 months postpartum)
FavorableUnfavorable or ambiguousNo Effect
22 months postpartum Nurse visited during pregnancy and comparison (Elmira) 188 mothers Adjusted mean = 0.31 Adjusted mean = 0.44 Mean difference = -0.13 Not available Statistical significance not reported
Number of pregnancies (0–22 months postpartum)
FavorableUnfavorable or ambiguousNo Effect
22 months, postpartum Nurse visited during pregnancy + infancy and comparison (Elmira) 196 mothers Adjusted mean = 0.38 Adjusted mean = 0.44 Mean difference = -0.06 Not available Not statistically significant, p ≥ 0.05
Submitted by user on
Statistical significance reported on authors’ calculations of the log-incidence difference.
Number of pregnancies (0–46 months postpartum)
FavorableUnfavorable or ambiguousNo Effect
46 months, postpartum Nurse visited during pregnancy and comparison (Elmira) 194 mothers Adjusted mean = 0.90 Adjusted mean = 1.06 Mean difference = -0.16 Not available Statistical significance not reported
Number of pregnancies (0–46 months postpartum)
FavorableUnfavorable or ambiguousNo Effect
46 months, postpartum Nurse visited during pregnancy + infancy and comparison (Elmira) 205 mothers Adjusted mean = 0.82 Adjusted mean = 1.06 Mean difference = -0.24 Not available Not statistically significant, p ≥ 0.05
Submitted by user on
Statistical significance reported on authors’ calculations of the log-incidence difference.
Number of spontaneous abortions (0–46 months postpartum)
FavorableUnfavorable or ambiguousNo Effect
46 months, postpartum Nurse visited during pregnancy and comparison (Elmira) 194 mothers Adjusted mean = 0.12 Adjusted mean = 0.13 Mean difference = -0.01 Not available Statistical significance not reported
Number of spontaneous abortions (0–46 months postpartum)
FavorableUnfavorable or ambiguousNo Effect
46 months, postpartum Nurse visited during pregnancy + infancy and comparison (Elmira) 205 mothers Adjusted mean = 0.10 Adjusted mean = 0.13 Mean difference = -0.03 Not available Not statistically significant, p ≥ 0.05
Submitted by user on
Statistical significance reported on authors’ calculations of the log-incidence difference.
Number of therapeutic abortions (0–46 months postpartum)
FavorableUnfavorable or ambiguousNo Effect
46 months, postpartum Nurse visited during pregnancy and comparison (Elmira) 194 mothers Adjusted mean = 0.05 Adjusted mean = 0.04 Mean difference = 0.01 Not available Statistical significance not reported
Number of therapeutic abortions (0–46 months postpartum)
FavorableUnfavorable or ambiguousNo Effect
46 months, postpartum Nurse visited during pregnancy + infancy and comparison (Elmira) 205 mothers Adjusted mean = 0.05 Adjusted mean = 0.04 Mean difference = 0.01 Not available Not statistically significant, p ≥ 0.05
Submitted by user on
Statistical significance reported on authors’ calculations of the log-incidence difference.
Nurse-Family Partnership (NFP)®
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance
Alcohol or other drug use
FavorableUnfavorable or ambiguousNo Effect
12-year follow-up Nurse visited during pregnancy and infancy and development screening comparison (Memphis) 594 mothers %(adjusted) = 10.00 Adjusted mean % = 10.00 OR = 0.91 HomVEE calculated = -0.05 Not statistically significant, p ≥ 0.05
Cumulative subsequent births
FavorableUnfavorable or ambiguousNo Effect
0 to 12 years Nurse visited during pregnancy and infancy and development screening comparison (Memphis) 594 mothers Adjusted mean = 1.07 Adjusted mean = 1.15 Mean difference = -0.08 HomVEE calculated = -1.69 Not statistically significant, p ≥ 0.05
Cumulative subsequent births
FavorableUnfavorable or ambiguousNo Effect
10 to 12 years Nurse visited during pregnancy and infancy and development screening comparison (Memphis) 594 mothers Adjusted mean = 1.80 Adjusted mean = 1.83 Mean difference = -0.03 HomVEE calculated = -0.42 Not statistically significant, p ≥ 0.05
Pearlin Mastery Scale
FavorableUnfavorable or ambiguousNo Effect
12-year follow-up Nurse visited during pregnancy + infancy and development screening comparison (Memphis) 594 mothers Adjusted mean = 101.07 Adjusted mean = 99.56 Mean difference = 1.51 HomVEE calculated = 2.80 Not statistically significant, p ≥ 0.05
Pearlin Mastery Scale
FavorableUnfavorable or ambiguousNo Effect
6 months to 12 years Nurse visited during pregnancy + infancy and development screening comparison (Memphis) 594 mothers Adjusted mean = 101.04 Adjusted mean = 99.60 Mean difference = 1.44 HomVEE calculated = 4.30 Statistically significant, p < .05
Role impairment due to alcohol or drug use
FavorableUnfavorable or ambiguousNo Effect
12-year follow-up Nurse visited during pregnancy and infancy and development screening comparison (Memphis) 594 mothers %(adjusted) = 0.00 Adjusted mean % = 3.00 Difference = -0.03 Not available Statistically significant, p < .05
Symptoms of psychological distress (borderline/clinical vs. normal)
FavorableUnfavorable or ambiguousNo Effect
12-year follow-up Nurse visited during pregnancy and infancy and development screening comparison (Memphis) 594 mothers %(adjusted) = 18.00 Adjusted mean % = 17.00 OR = 1.09 HomVEE calculated = 0.05 Not statistically significant, p ≥ 0.05
Nurse-Family Partnership (NFP)®
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes

Beck Anxiety Screening Inventory, clinical or borderline threshold

FavorableUnfavorable or ambiguousNo Effect

18 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

617 mothers Adjusted proportion = 0.09 Adjusted proportion = 0.10 Odds ratio = 0.94 HomVEE calculated = -0.04

Not statistically significant, p= 0.82

Submitted by user on

Negative effect is favorable to the intervention.

Submitted by barbara on

HomVEE calculated the effect size based on the study-reported odds ratio.

Beck Depression Screening Inventory, Maternal depression, clinical or borderline threshold

FavorableUnfavorable or ambiguousNo Effect

18 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

617 mothers Adjusted proportion = 0.09 Adjusted proportion = 0.08 Odds ratio = 1.12 HomVEE calculated = 0.07

Not statistically significant, p= 0.72

Submitted by user on

Negative effect is favorable to the intervention.

Submitted by barbara on

HomVEE calculated the effect size based on the study-reported odds ratio.

Drug Use Screening Inventory (DUSI), current substance use

FavorableUnfavorable or ambiguousNo Effect

18 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

617 mothers Adjusted proportion = 0.24 Adjusted proportion = 0.27 Odds ratio = 0.87 HomVEE calculated = -0.08

Not statistically significant, p= 0.49

Submitted by user on

Negative effect is favorable to the intervention.

Submitted by barbara on

HomVEE calculated the effect size based on the study-reported odds ratio.

Mothers' subsequent births

FavorableUnfavorable or ambiguousNo Effect

1 year

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

694 mothers Adjusted mean = 0.00 Adjusted mean = 0.04 Mean difference = -0.04 HomVEE calculated = -0.30

Statistically significant, p = 0.00

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Mothers' subsequent births

FavorableUnfavorable or ambiguousNo Effect

10 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

645 mothers Adjusted mean = 1.68 Adjusted mean = 1.74 Mean difference = -0.06 HomVEE calculated = -0.05

Not statistically significant, p = 0.58

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Mothers' subsequent births

FavorableUnfavorable or ambiguousNo Effect

11 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

643 mothers Adjusted mean = 1.78 Adjusted mean = 1.85 Mean difference = -0.07 HomVEE calculated = -0.05

Not statistically significant, p = 0.54

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Mothers' subsequent births

FavorableUnfavorable or ambiguousNo Effect

12 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

643 mothers Adjusted mean = 1.87 Adjusted mean = 1.93 Mean difference = -0.06 HomVEE calculated = -0.04

Not statistically significant, p = 0.62

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Mothers' subsequent births

FavorableUnfavorable or ambiguousNo Effect

13 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

629 mothers Adjusted mean = 1.94 Adjusted mean = 2.00 Mean difference = -0.06 HomVEE calculated = -0.04

Not statistically significant, p = 0.64

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Mothers' subsequent births

FavorableUnfavorable or ambiguousNo Effect

14 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

618 mothers Adjusted mean = 1.99 Adjusted mean = 2.05 Mean difference = -0.06 HomVEE calculated = -0.04

Not statistically significant, p = 0.65

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Mothers' subsequent births

FavorableUnfavorable or ambiguousNo Effect

15 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

618 mothers Adjusted mean = 2.03 Adjusted mean = 2.09 Mean difference = -0.06 HomVEE calculated = -0.04

Not statistically significant, p = 0.66

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Mothers' subsequent births

FavorableUnfavorable or ambiguousNo Effect

16 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

618 mothers Adjusted mean = 2.07 Adjusted mean = 2.13 Mean difference = -0.06 HomVEE calculated = -0.04

Not statistically significant, p = 0.67

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Mothers' subsequent births

FavorableUnfavorable or ambiguousNo Effect

17 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

618 mothers Adjusted mean = 2.09 Adjusted mean = 2.17 Mean difference = -0.08 HomVEE calculated = -0.05

Not statistically significant, p = 0.57

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Mothers' subsequent births

FavorableUnfavorable or ambiguousNo Effect

18 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

574 mothers Adjusted mean = 2.12 Adjusted mean = 2.21 Mean difference = -0.09 HomVEE calculated = -0.05

Not statistically significant, p = 0.54

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Mothers' subsequent births

FavorableUnfavorable or ambiguousNo Effect

2 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

686 mothers Adjusted mean = 0.15 Adjusted mean = 0.24 Mean difference = -0.09 HomVEE calculated = -0.25

Statistically significant, p = 0.00

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Mothers' subsequent births

FavorableUnfavorable or ambiguousNo Effect

3 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

681 mothers Adjusted mean = 0.39 Adjusted mean = 0.53 Mean difference = -0.14 HomVEE calculated = -0.25

Statistically significant, p = 0.00

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Mothers' subsequent births

FavorableUnfavorable or ambiguousNo Effect

4 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

681 mothers Adjusted mean = 0.62 Adjusted mean = 0.78 Mean difference = -0.16 HomVEE calculated = -0.24

Statistically significant, p = 0.00

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Mothers' subsequent births

FavorableUnfavorable or ambiguousNo Effect

5 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

670 mothers Adjusted mean = 0.83 Adjusted mean = 1.00 Mean difference = -0.17 HomVEE calculated = -0.22

Statistically significant, p = 0.01

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Mothers' subsequent births

FavorableUnfavorable or ambiguousNo Effect

6 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

668 mothers Adjusted mean = 1.05 Adjusted mean = 1.20 Mean difference = -0.15 HomVEE calculated = -0.17

Statistically significant, p < 0.05

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Mothers' subsequent births

FavorableUnfavorable or ambiguousNo Effect

7 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

660 mothers Adjusted mean = 1.23 Adjusted mean = 1.38 Mean difference = -0.15 HomVEE calculated = -0.15

Not statistically significant, p = 0.08

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Mothers' subsequent births

FavorableUnfavorable or ambiguousNo Effect

8 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

658 mothers Adjusted mean = 1.41 Adjusted mean = 1.54 Mean difference = -0.13 HomVEE calculated = -0.12

Not statistically significant, p = 0.17

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Mothers' subsequent births

FavorableUnfavorable or ambiguousNo Effect

9 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

658 mothers Adjusted mean = 1.55 Adjusted mean = 1.65 Mean difference = -0.10 HomVEE calculated = -0.08

Not statistically significant, p = 0.32

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Pearlin Mastery Scale

FavorableUnfavorable or ambiguousNo Effect

12 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

582 mothers Unadjusted mean = 100.59 Unadjusted mean = 99.71 Mean difference = 0.88 HomVEE calculated = 0.09

Not statistically significant, p = 0.32

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Pearlin Mastery Scale

FavorableUnfavorable or ambiguousNo Effect

18 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

616 mothers Adjusted proportion = 100.74 Adjusted proportion = 99.69 Mean difference = 1.05 Study reported = 1.98

Not statistically significant, p= 0.19

Pearlin Mastery Scale

FavorableUnfavorable or ambiguousNo Effect

2 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

670 mothers Unadjusted mean = 101.28 Unadjusted mean = 99.41 Mean difference = 1.87 HomVEE calculated = 0.19

Statistically significant, p = 0.03

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Pearlin Mastery Scale

FavorableUnfavorable or ambiguousNo Effect

36th week of pregnancy

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

657 mothers Unadjusted mean = 101.00 Unadjusted mean = 99.56 Mean difference = 1.44 HomVEE calculated = 0.14

Not statistically significant, p = 0.09

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Pearlin Mastery Scale

FavorableUnfavorable or ambiguousNo Effect

6 months

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

666 mothers Unadjusted mean = 100.47 Unadjusted mean = 99.82 Mean difference = 0.65 HomVEE calculated = 0.07

Not statistically significant, p = 0.44

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Pearlin Mastery Scale

FavorableUnfavorable or ambiguousNo Effect

6 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

635 mothers Unadjusted mean = 100.26 Unadjusted mean = 99.87 Mean difference = 0.39 HomVEE calculated = 0.04

Not statistically significant, p = 0.65

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Pearlin Mastery Scale

FavorableUnfavorable or ambiguousNo Effect

9 years

NFP vs. Resource referral RCT, Memphis TN, 1990-2015, full sample

625 mothers Unadjusted mean = 100.37 Unadjusted mean = 99.83 Mean difference = 0.54 HomVEE calculated = 0.05

Not statistically significant, p = 0.53

Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Nurse-Family Partnership (NFP)®
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes
MHI
FavorableUnfavorable or ambiguousNo Effect
6-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 641 mothers Adjusted mean = 100.18 Adjusted mean = 99.92 Mean difference = 0.26 Study reported = 0.03 Not statistically significant,
p = 0.76
Behavioral problems attributable to substance abuse
FavorableUnfavorable or ambiguousNo Effect
6-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 641 mothers % (adjusted) = 4.00 Adjusted mean % = 4.00 OR = 0.94 HomVEE calculated = -0.03 Not statistically significant,
p = 0.88
Submitted by user on
Statistical significance reported on authors’ calculations of the odds ratio.
Currently uses marijuana
FavorableUnfavorable or ambiguousNo Effect
6-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 641 mothers % (adjusted) = 5.00 Adjusted mean % = 3.00 OR = 1.37 HomVEE calculated = 0.19 Not statistically significant,
p = 0.47
Submitted by user on
Statistical significance reported on authors’ calculations of the odds ratio.
Moderate/heavy drinker (= 3 drinks = 3 times per month)
FavorableUnfavorable or ambiguousNo Effect
6-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 641 mothers % (adjusted) = 5.00 Adjusted mean % = 3.00 OR = 2.03 HomVEE calculated = 0.44 Not statistically significant,
p = 0.11
Submitted by user on
Statistical significance reported on authors’ calculations of the odds ratio.
Months between births of first and second children
FavorableUnfavorable or ambiguousNo Effect
6-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 641 mothers Adjusted mean = 34.38 Adjusted mean = 30.23 Mean difference = 4.15 Study reported = 0.26 Statistically significant,
p = 0.01
Number of subsequent children (birth to 72 months postpartum)
FavorableUnfavorable or ambiguousNo Effect
6-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 641 mothers Adjusted mean = 1.08 Adjusted mean = 1.28 Mean difference = -0.20 Study reported = -0.22 Statistically significant,
p = 0.01
Number of subsequent pregnancies (birth to 72 months postpartum)
FavorableUnfavorable or ambiguousNo Effect
6-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 641 mothers Adjusted mean = 1.16 Adjusted mean = 1.38 Mean difference = -0.22 Study reported = -0.22 Statistically significant,
p = 0.01
Pearlin Mastery Scale
FavorableUnfavorable or ambiguousNo Effect
6-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 641 mothers Adjusted mean = 100.46 Adjusted mean = 99.79 Mean difference = 0.67 Study reported = 0.07 Not statistically significant,
p = 0.43
Subsequent abortion (rate per subsequent pregnancy)
FavorableUnfavorable or ambiguousNo Effect
6-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 641 mothers % (adjusted) = 4.00 Adjusted mean % = 5.00 OR = 0.70 HomVEE calculated = -0.23 Not statistically significant,
p = 0.42
Submitted by user on
Statistical significance reported on authors’ calculations of the odds ratio.
Subsequent miscarriage (rate per subsequent pregnancy)
FavorableUnfavorable or ambiguousNo Effect
6-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 641 mothers % (adjusted) = 3.00 Adjusted mean % = 5.00 OR = 0.75 HomVEE calculated = -0.27 Not statistically significant,
p = 0.50
Submitted by user on
Statistical significance reported on authors’ calculations of the odds ratio.
Nurse-Family Partnership (NFP)®
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes
Cumulative subsequent live birth per year (6–9 years postpartum)
FavorableUnfavorable or ambiguousNo Effect
9-year follow-up Nurse visited during pregnancy + infancy during infancy and developmental screening comparison (Memphis) 627 mothers Adjusted mean = 1.40 Adjusted mean = 1.53 Mean difference = -0.13 Study reported = -0.16 Not statistically significant,
p = 0.17
Submitted by user on
Statistical significance reported on authors’ calculations of the odds ratio.
Cumulative subsequent live births per year (0–9 yr postpartum)
FavorableUnfavorable or ambiguousNo Effect
9-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 627 mothers Adjusted mean = 0.81 Adjusted mean = 0.93 Mean difference = -0.12 Study reported = -0.14 Statistically significant,
p < 0.05
Submitted by user on
Statistical significance reported on authors’ calculations of the odds ratio.
Maternal depression (CES-D) (9 years postpartum)
FavorableUnfavorable or ambiguousNo Effect
9-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 627 mothers Adjusted mean = 1.71 Adjusted mean = 1.72 Mean difference = 0.01 Study reported = -0.01 Not statistically significant,
p = 0.87
Submitted by user on
Statistical significance reported on authors’ calculations of the odds ratio.
Number of months between birth of first and second child
FavorableUnfavorable or ambiguousNo Effect
9-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 627 mothers Adjusted mean = 40.73 Adjusted mean = 34.09 Mean difference = 6.64 Study reported = 0.29 Statistically significant,
p < 0.01
Submitted by user on
Statistical significance reported on authors’ calculations of the odds ratio.
Number of subsequent abortions
FavorableUnfavorable or ambiguousNo Effect
9-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 627 mothers Adjusted mean = 0.14 Adjusted mean = 0.20 Mean difference = -0.06 Not available Not statistically significant,
p = 0.15
Submitted by user on
Statistical significance reported on authors’ calculation of incidence ratio.
Number of subsequent miscarriages (0–9 years postpartum)
FavorableUnfavorable or ambiguousNo Effect
9-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 627 mothers Adjusted mean = 0.24 Adjusted mean = 0.24 Mean difference = 0.00 Not available Not statistically significant,
p = 1.00
Submitted by user on
Statistical significance reported on authors’ calculation of incidence ratio.
Number of substances used (moderate/heavy alcohol, marijuana, cocaine) since last interview
FavorableUnfavorable or ambiguousNo Effect
9-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 627 mothers Adjusted mean = 0.10 Adjusted mean = 0.17 Mean difference = -0.07 Not available Not statistically significant,
p = 0.08
Submitted by user on
Statistical significance reported on authors’ calculation of incidence ratio.
Pearlin Mastery Scale (9 years postpartum)
FavorableUnfavorable or ambiguousNo Effect
9-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 627 mothers Adjusted mean = 100.79 Adjusted mean = 99.75 Mean difference = 1.04 Study reported = 0.10 Not statistically significant,
p = 0.20
Submitted by user on
Statistical significance reported on authors’ calculations of the odds ratio.
Pearlin Mastery Scale (6 months–9 years postpartum)
FavorableUnfavorable or ambiguousNo Effect
9-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 627 mothers Adjusted mean = 101.00 Adjusted mean = 99.50 Mean difference = 1.53 Study reported = 0.15 Statistically significant,
p < 0.01
Submitted by user on
Statistical significance reported on authors’ calculations of the odds ratio.
Subsequent still birth (0–9 years postpartum), percentage
FavorableUnfavorable or ambiguousNo Effect
9-year follow-up Nurse visited during pregnancy + infancy and developmental screening comparison (Memphis) 627 mothers % (adjusted) = 1.00 Adjusted mean % = 2.00 Mean difference = -1.00 Study reported = 1.00 Not statistically significant,
p = 0.36
Submitted by user on
Statistical significance reported on authors’ calculations of the odds ratio.
Nurse-Family Partnership (NFP)®
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance
Subsequent birth (24 months postpartum)
FavorableUnfavorable or ambiguousNo Effect
24 months Nurse home visitor and comparison (Denver) 436 mothers % (adjusted) = 12.00 Adjusted mean % = 19.00 OR = 0.58 HomVEE calculated = -0.33 Statistically significant,
p ≤ 0.05
Subsequent pregnancy (24 months postpartum)
FavorableUnfavorable or ambiguousNo Effect
24 months Nurse home visitor and comparison (Denver) 436 mothers % (adjusted) = 29.00 Adjusted mean % = 41.00 OR = 0.60 HomVEE calculated = -0.32 Statistically significant,
p ≤ 0.05
Nurse-Family Partnership (NFP)®
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance
MHI
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Nurse home visitor and comparison (Denver) 424 mothers Adjusted mean = 99.82 Adjusted mean = 99.16 Mean difference = 0.66 Study reported = 0.04 Not statistically significant,
p = 0.49
Behavioral problems attributable to substance use
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Nurse home visitor and comparison (Denver) 424 mothers = 0.15 = 0.12 OR = 1.27 HomVEE calculated = 0.15 Not statistically significant,
p = 0.41
Currently using marijuana
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Nurse home visitor and comparison (Denver) 424 mothers = 0.08 = 0.09 OR = 0.86 HomVEE calculated = -0.09 Not statistically significant,
p = 0.67
Moderate/heavy drinker (= 3 drinks, = 3 times in 14 days)
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Nurse home visitor and comparison (Denver) 424 mothers = 0.04 = 0.04 OR = 1.09 HomVEE calculated = 0.06 Not statistically significant,
p = 0.84
Months between births of first and second children
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Nurse home visitor and comparison (Denver) 424 mothers Adjusted mean = 24.51 Adjusted mean = 20.39 Mean difference = 4.12 Study reported = 0.32 Statistically significant,
p = 0.01
Number of subsequent live births
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Nurse home visitor and comparison (Denver) 424 mothers Adjusted mean = 0.48 Adjusted mean = 0.57 Mean difference = -0.09 Study reported = -0.13 Not statistically significant,
p = 0.18
Number of subsequent pregnancies
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Nurse home visitor and comparison (Denver) 424 mothers Adjusted mean = 0.85 Adjusted mean = 0.88 Mean difference = -0.03 Study reported = -0.04 Not statistically significant,
p = 0.72
Pearlin Mastery Scale
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Nurse home visitor and comparison (Denver) 424 mothers Adjusted mean = 99.41 Adjusted mean = 99.31 Mean difference = 0.10 Study reported = 0.12 Not statistically significant,
p = 0.91
Subsequent abortion
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Nurse home visitor and comparison (Denver) 424 mothers = 0.05 = 0.05 OR = 0.94 HomVEE calculated = -0.04 Not statistically significant,
p = 0.89
Subsequent miscarriage
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Nurse home visitor and comparison (Denver) 424 mothers = 0.09 = 0.12 OR = 0.73 HomVEE calculated = -0.19 Not statistically significant,
p = 0.31
NFP with Paraprofessional Home Visitors
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes
Subsequent birth (24 months postpartum)
FavorableUnfavorable or ambiguousNo Effect
24 months Paraprofessional home visitor and comparison (Denver) 417 mothers % (adjusted) = 13.00 Adjusted mean % = 19.00 OR = 0.63 HomVEE calculated = -0.27 Not statistically significant, p > 0.05
Submitted by user on
Authors report the difference in this outcome to be statistically significant, p < 0.10, which is greater than the acceptable alpha for this review (α = 0.05).
Subsequent pregnancy (24 months postpartum)
FavorableUnfavorable or ambiguousNo Effect
24 months Paraprofessional home visitor and comparison (Denver) 417 mothers % (adjusted) = 33.00 Adjusted mean % = 41.00 OR = 0.70 HomVEE calculated = -0.21 Not statistically significant, p > 0.05
Submitted by user on
Authors report the difference in this outcome to be statistically significant, p < 0.10, which is greater than the acceptable alpha for this review (α = 0.05).
Use of emergency services
FavorableUnfavorable or ambiguousNo Effect
36 weeks (prenatal) Paraprofessional home visitor and comparison (Denver) 344 mothers % (adjusted) = 9.00 Adjusted mean % = 9.00 OR = 1.01 HomVEE calculated = 0.00 Not statistically significant,
p > 0.05
Use of preventative services
FavorableUnfavorable or ambiguousNo Effect
36 weeks (prenatal) Paraprofessional home visitor and comparison (Denver) 344 mothers Adjusted mean = 0.67 Adjusted mean = 0.69 Mean difference = -0.02 Not available Not statistically significant,
p > 0.05

Findings rated moderate

Nurse-Family Partnership (NFP)®
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes
Alcohol impairment score
FavorableUnfavorable or ambiguousNo Effect
15 years Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample 300 mothers Unadjusted mean = 0.35 Unadjusted mean = 0.37 MD = -0.02 HomVEE calculated = -0.02 Not statistically significant, p = 0.87
Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Substance use - # cigarettes smoked per day
FavorableUnfavorable or ambiguousNo Effect
15 years Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample 300 mothers Unadjusted mean = 8.32 Unadjusted mean = 10.56 MD = -2.24 HomVEE calculated = -0.21 Not statistically significant, p = 0.11
Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Substance use - binge drinking: # days had 5+ drinks in the past year
FavorableUnfavorable or ambiguousNo Effect
15 years Nurse-visited group 4 vs. comparison groups 1 and 2, Elmira sample 300 mothers Unadjusted mean = 11.70 Unadjusted mean = 9.27 MD = 2.43 HomVEE calculated = 0.06 Not statistically significant, p = 0.65
Submitted by nwu on

Statistical significance is based on HomVEE calculations.

Nurse-Family Partnership (NFP)®
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance
Use of emergency services
FavorableUnfavorable or ambiguousNo Effect
36 weeks (prenatal) Nurse home visitor and comparison (Denver) 353 mothers % (adjusted) = 6.00 Adjusted mean % = 9.00 OR = 0.64 HomVEE calculated = -0.27 Not statistically significant,
p > 0.05
Use of preventative services
FavorableUnfavorable or ambiguousNo Effect
36 weeks (prenatal) Nurse home visitor and comparison (Denver) 353 mothers Adjusted mean = 0.80 Adjusted mean = 0.69 Mean difference = 0.11 HomVEE calculated = 0.09 Not statistically significant,
p > 0.05
Nurse-Family Partnership (NFP)®
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance Notes
21 year maternal mortality rate - all causes (Nurse home visits during pregnancy and infancy vs. transport to prenatal appointment comparison)
FavorableUnfavorable or ambiguousNo Effect
21 years Nurse home visits during pregnancy and infancy vs. transport to prenatal appointment comparison (Memphis) 1138 mother/child dyads Unadjusted mean = 0.01 Unadjusted mean = 0.04 Mean difference = -0.03 HomVEE calculated = -0.69 Statistically significant, p = 0.01
Submitted by user on
Negative value is favorable to the intervention.
21 year maternal mortality rate - all causes (Nurse home visits during pregnancy and infancy vs. transport to prenatal appointment comparison)
FavorableUnfavorable or ambiguousNo Effect
21 years Nurse home visits during pregnancy and infancy vs. transport to prenatal appointment comparison (Memphis) 1138 mother/child dyads Unadjusted mean = 0.01 Unadjusted mean = 0.04 Mean difference = -0.03 HomVEE calculated = -0.69 Statistically significant, p = 0.01
Submitted by user on
Negative value is favorable to the intervention.
21 year maternal mortality rate - all causes (Nurse home visits during pregnancy plus 2 postpartum visits vs. transport to prenatal appointment comparison)
FavorableUnfavorable or ambiguousNo Effect
21 years Nurse home visits during pregnancy plus 2 postpartum visits vs. transport to prenatal appointment comparison (Memphis) 910 mother/child dyads Unadjusted mean = 0.00 Unadjusted mean = 0.04 Mean difference = -0.04 HomVEE calculated = -1.41 Statistically significant, p = 0.01
Submitted by user on
Negative value is favorable to the intervention.
21 year maternal mortality rate - external cause (Nurse home visits during pregnancy and infancy vs. transport to prenatal appointment comparison)
FavorableUnfavorable or ambiguousNo Effect
21 years Nurse home visits during pregnancy and infancy vs. transport to prenatal appointment comparison (Memphis) 1138 mother/child dyads Unadjusted mean = 0.00 Unadjusted mean = 0.02 Mean difference = -0.01 HomVEE calculated = -1.22 Statistically significant, p = 0.02
Submitted by user on
Negative value is favorable to the intervention.
21 year maternal mortality rate - external cause (Nurse home visits during pregnancy and infancy vs. transport to prenatal appointment comparison)
FavorableUnfavorable or ambiguousNo Effect
21 years Nurse home visits during pregnancy and infancy vs. transport to prenatal appointment comparison (Memphis) 1138 mother/child dyads Unadjusted mean = 0.00 Unadjusted mean = 0.02 Mean difference = -0.01 HomVEE calculated = -1.22 Statistically significant, p = 0.02
Submitted by user on
Negative value is favorable to the intervention.
21 year maternal mortality rate - external cause (Nurse home visits during pregnancy plus 2 postpartum visits vs. transport to prenatal appointment comparison)
FavorableUnfavorable or ambiguousNo Effect
21 years Nurse home visits during pregnancy plus 2 postpartum visits vs. transport to prenatal appointment comparison (Memphis) 910 mother/child dyads Unadjusted mean = 0.00 Unadjusted mean = 0.02 Mean difference = -0.02 Not available Not statistically significant, p = 0.05
Submitted by user on
Negative value is favorable to the intervention.
NFP with Paraprofessional Home Visitors
Show findings details
Outcome measure Effect Follow-up timing Sample Sample size Intervention group Comparison group Group difference Effect size Statistical significance
MHI
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Paraprofessional home visitor and comparison (Denver) 431 mothers Adjusted mean = 101.20 Adjusted mean = 99.16 Mean difference = 0.66 Study reported = -0.03 Statistically significant,
p = 0.03
Behavioral problems attributable to substance use
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Paraprofessional home visitor and comparison (Denver) 431 mothers = 0.10 = 0.12 OR = 0.82 HomVEE calculated = -0.12 Not statistically significant,
p = 0.52
Currently using marijuana
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Paraprofessional home visitor and comparison, (Denver) 431 mothers = 0.09 = 0.09 OR = 0.94 HomVEE calculated = -0.04 Not statistically significant,
p = 0.87
Moderate/heavy drinker (= 3 drinks, = 3 times in 14 days)
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Paraprofessional home visitor and comparison (Denver) 431 mothers = 0.03 = 0.04 OR = 0.74 HomVEE calculated = -0.21 Not statistically significant,
p = 0.54
Months between births of first and second children
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Paraprofessional home visitor and comparison (Denver) 431 mothers Adjusted mean = 22.20 Adjusted mean = 20.39 Mean difference = 1.81 Study reported = 0.14 Not statistically significant,
p = 0.27
Number of subsequent live births
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Paraprofessional home visitor and comparison (Denver) 431 mothers Adjusted mean = 0.53 Adjusted mean = 0.57 Mean difference = -0.04 Study reported = -0.06 Not statistically significant,
p = 0.57
Number of subsequent pregnancies
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Paraprofessional home visitor and comparison (Denver) 431 mothers Adjusted mean = 0.88 Adjusted mean = 0.88 Mean difference = 0.00 Study reported = 0.00 Not statistically significant,
p = 1.00
Pearlin Mastery Scale
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Paraprofessional home visitor and comparison (Denver) 431 mothers Adjusted mean = 101.20 Adjusted mean = 99.31 Mean difference = 1.94 Study reported = 0.20 Statistically significant,
p = 0.03
Subsequent abortion
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Paraprofessional home visitor and comparison (Denver) 431 mothers = 0.06 = 0.05 OR = 1.19 HomVEE calculated = 0.10 Not statistically significant,
p = 0.67
Subsequent miscarriage
FavorableUnfavorable or ambiguousNo Effect
4-year follow-up Paraprofessional home visitor and comparison (Denver) 431 mothers = 0.07 = 0.12 OR = 0.50 HomVEE calculated = -0.42 Statistically significant,
p = 0.04
View Revisions