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Childhood Asthma Prevention Study (CAPS)

Last Updated: October 2012

In Brief for Child Health Outcomes

Impact Studies Rated High


Klinnert, M. D., Liu, A. H., Pearson, M. R., Ellison, M. C., Budhiraja, N., & Robinson, J. L. (2005). Short-term impact of a randomized multifaceted intervention for wheezing infants in low-income families. Archives of Pediatrics & Adolescent Medicine, 159(1), 75-82.
Show Study Effects Details
Outcome Effect Sample Timing of Follow-Up Sample Size Program Group Comparison Group Mean Difference or Odds Ratio
Statistical Significance
Effect Size
Outcome Type
Cotinine level1 No Effect Denver, Colorado sample 12 months 130 children 0.66 0.56 MD = . 1 Not statistically significant, p = 0.28 HomVEE = 0.25 Primary
Functional Severity Score No Effect Denver, Colorado sample 12 months 150 children Mean = 1.03 Mean = 1.04 MD = -0.01 Not Statistically significant, p = 0.60 Not available Secondary

1 Cotinine level outcome based on logistic regression model. Outcome from logrnormal regression model had high attrition and is not included in this report.

Show Study Outcome Measure Summary
Outcome Description of Measure Data Collection Method Properties of the Outcome Measure Outcome Type
Cotinine level The authors measured cotinine levels to detect environmental tobacco smoke exposure. The measure indicates the percentage of infants in whom cotinine levels, a metabolite of nicotine, were greater than 5 nanograms of cotinine per gram of creatinine. Infant urine samples Not applicable Primary
Functional Severity Score Incidence and severity of infant respiratory symptoms over the past six months. Parent/caregiver report Not applicable Secondary

Klinnert, M. D., Liu, A. H., Pearson, M. R., Tong, S., Strand, M, Luckow, A., & Robinson, J. L. (2007). Outcome of a randomized multifaceted intervention with low-income families of wheezing infants. Archives of Pediatrics & Adolescent Medicine, 161(8), 783-790.
Show Study Effects Details
Outcome Effect Sample Timing of Follow-Up Sample Size Program Group Comparison Group Mean Difference or Odds Ratio
Statistical Significance
Effect Size
Outcome Type
Emergency Department Visits No Effect Denver, CO sample Between 24 and 34 months 144 children Unadjusted mean = 18. 6 Unadjusted mean = 24.3 OR = .85 Not statistically significant, p = .72 HomVEE = .01 Primary
Oral corticosteroid use No Effect Denver, CO sample Between 24 and 34 months 144 children Unadjusted mean = 18. 6 Unadjusted mean = 24.3 OR = .69 Not statistically significant, p = .44 HomVEE = .01 Primary
Show Study Outcome Measure Summary
Outcome Description of Measure Data Collection Method Properties of the Outcome Measure Outcome Type
Emergency Department Visits Percentage of child emergency department visits between three and four years of age Review of medical records Not applicable Primary
Oral corticosteroid use Percentage of children who had a course of oral corticosteroids during the previous year. Review of medical records Not applicable Primary
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